Microemulsion systems: from the design and architecture to the building of a new delivery system for multiple-route drug delivery

EST Egito, L Amaral-Machado, EN Alencar… - Drug Delivery and …, 2021 - Springer
Poorly soluble active pharmaceutical ingredients (APIs) create major problems in drug
dosage form formulation resulting in significant delays in drug pharmaceutical screening …

Quality characteristics and moisture migration of refrigerated bullfrog (Lithobates catesbeiana) under slightly acidic electrolyzed water combined with composite …

J Du, W Lan, J Xie - Food Bioscience, 2023 - Elsevier
The aim of this study was to investigate the effects of allicin and antioxidant of bamboo
leaves (AOB) with slightly acidic electrolyzed water (SAEW) pretreatment on the …

Remedying the mitochondria to cure human diseases by natural products

JK Mu, YQ Li, TT Shi, LP Yu, YQ Yang… - Oxidative Medicine …, 2020 - Wiley Online Library
Mitochondria are the 'engine'of cells. Mitochondrial dysfunction is an important mechanism
in many human diseases. Many natural products could remedy the mitochondria to alleviate …

[HTML][HTML] 22β-hydroxytingenone induces apoptosis and suppresses invasiveness of melanoma cells by inhibiting MMP-9 activity and MAPK signaling

ESP Aranha, AJ de Sousa Portilho, LB de Sousa… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance 22β-hydroxytingenone (22-HTG) is a
quinonemethide triterpene isolated from Salacia impressifolia (Miers) AC Smith (family …

Copaiba oil-loaded polymeric nanocapsules: production and in vitro biosafety evaluation on lung cells as a pre-formulation step to produce phytotherapeutic medicine

VM Rodrigues, WN Oliveira, DT Pereira, ÉN Alencar… - Pharmaceutics, 2023 - mdpi.com
Copaiba oil has been largely used due to its therapeutic properties. Nanocapsules were
revealed to be a great nanosystem to carry natural oils due to their ability to improve the …

Ferri–Liposomes: Preformulation and selective cytotoxicity against A549 lung cancer cells

MGF de Souza, FN de Jesus Guedes, ML Tebaldi… - Pharmaceutics, 2021 - mdpi.com
Liposomes have become successful nanostructured systems used in clinical practices.
These vesicles are able to carry important drug loadings with noteworthy stability. The aim of …

Epimedium sagittatum Maxim ameliorates adriamycin‐induced nephropathy by restraining inflammation and apoptosis via the PI3K/AKT signaling pathway

R Wang, M Zeng, B Zhang, Q Zhang… - Immunity …, 2023 - Wiley Online Library
Background Modern pharmacological studies show that Epimedium sagittatum Maxim (EPI)
has antioxidant, antiapoptotic, anti‐inflammatory effects. However, the effects of EPI on …

Cocoa presents cytotoxicity against melanoma cancer cell lines (A‐375 e B16‐F10) and improves chemotherapy activity by increasing oxidative stress

GH Mello, CMS D'Ávila, AR Viana… - Journal of Food …, 2022 - Wiley Online Library
Melanoma frequently presents a poor chemotherapy response. In this scenario,
investigations for new therapies are essential. Thus, cocoa is highlighted in this area since it …

[HTML][HTML] Nanostructured systems increase the in vitro cytotoxic effect of bullfrog oil in human melanoma cells (A2058)

WN Oliveira, EN Alencar, HAO Rocha… - Biomedicine & …, 2022 - Elsevier
The aim of this work was to investigate the in vitro cytotoxic effect of previously developed
nanocapsules, nanoemulsion, and microemulsion based on bullfrog oil (BFO) against …

A new amide alkaloid induces the apoptosis of human melanoma A375 cells via inhibition of the STAT3 signaling pathway

R Wang, B Yang, B Zhang, Q Zhang, B Cao… - New Journal of …, 2023 - pubs.rsc.org
Melanoma is the deadliest invasive skin cancer, posing a serious threat to human health.
Emerging evidence has shown that STAT3 is a major oncogene in melanoma and validated …