[HTML][HTML] Inflammation and tumor progression: signaling pathways and targeted intervention

H Zhao, L Wu, G Yan, Y Chen, M Zhou… - Signal transduction and …, 2021 - nature.com
Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

[HTML][HTML] Tumor-associated neutrophils and neutrophil-targeted cancer therapies

H Que, Q Fu, T Lan, X Tian, X Wei - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Neutrophils are the frontline cells in response to microbial infections and are involved in a
range of inflammatory disorders in the body. In recent years, neutrophils have gained …

Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression

K Fousek, LA Horn, C Palena - Pharmacology & therapeutics, 2021 - Elsevier
Tumor progression relies on the ability of cancer cells to effectively invade surrounding
tissues and propagate. Among the many mechanisms that contribute to tumor progression is …

Structural basis of CXC chemokine receptor 2 activation and signalling

K Liu, L Wu, S Yuan, M Wu, Y Xu, Q Sun, S Li, S Zhao… - Nature, 2020 - nature.com
Chemokines and their receptors mediate cell migration, which influences multiple
fundamental biological processes and disease conditions such as inflammation and cancer …

Blood molecular markers associated with COVID‐19 immunopathology and multi‐organ damage

YM Chen, Y Zheng, Y Yu, Y Wang, Q Huang… - The EMBO …, 2020 - embopress.org
COVID‐19 is characterized by dysregulated immune responses, metabolic dysfunction and
adverse effects on the function of multiple organs. To understand host responses to COVID …

[HTML][HTML] Chemokine-directed tumor microenvironment modulation in cancer immunotherapy

P Bule, SI Aguiar, F Aires-Da-Silva… - International journal of …, 2021 - mdpi.com
Chemokines are a large family of small chemotactic cytokines that coordinates immune cell
trafficking. In cancer, they have a pivotal role in the migration pattern of immune cells into the …

[HTML][HTML] Multiple roles for chemokines in neutrophil biology

A Capucetti, F Albano, R Bonecchi - Frontiers in immunology, 2020 - frontiersin.org
Chemokines are recognized as the most critical mediators for selective neutrophil
recruitment during inflammatory conditions. Furthermore, they are considered fundamental …

[HTML][HTML] Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin

Y Cheng, F Mo, Q Li, X Han, H Shi, S Chen, Y Wei… - Molecular cancer, 2021 - Springer
Background Drug-resistance and severe side effects of chemotherapeutic agents result in
unsatisfied survival of patients with lung cancer. CXCLs/CXCR2 axis plays an important role …

[HTML][HTML] CXCL8 in tumor biology and its implications for clinical translation

X Xiong, X Liao, S Qiu, H Xu, S Zhang… - Frontiers in molecular …, 2022 - frontiersin.org
The chemokine CXCL8 has been found to play an important role in tumor progression in
recent years. CXCL8 activates multiple intracellular signaling pathways by binding to its …

[HTML][HTML] Tumor regionalization after surgery: Roles of the tumor microenvironment and neutrophil extracellular traps

SB Kwak, SJ Kim, J Kim, YL Kang, CW Ko… - … & Molecular Medicine, 2022 - nature.com
Surgery is unanimously regarded as the primary strategy to cure solid tumors in the early
stages but is not always used in advanced cases. However, tumor surgery must be carefully …