Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …

Matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs)
belong to the metzincin family of zinc-containing multidomain molecules, and can act as …

Molecular analysis on the single-cell level represents a rapidly growing field in the life
sciences. While bulk analysis from a pool of cells provides a general molecular profile, it is …

CD90 is a membrane GPI-anchored protein with one Ig V-type superfamily domain that was
initially described in mouse T cells. Besides the specific expression pattern and functions of …

Characterised by high intra‐and inter‐tumor heterogeneity, metastatic renal cell carcinoma
(RCC) is resistant to chemo‐and radiotherapy. Therefore, the development of new …

Background: Cancer stem cells (CSCs) are biologically characterized by self-renewal, multi-
directional differentiation and infinite proliferation, inducing anti-tumor drug resistance and …

Renal cell carcinoma (RCC) is a deadly malignancy due to its tendency to metastasize and
resistance to chemotherapy. Stem-like tumor cells often confer these aggressive behaviors …

The term cancer stem cell (CSC) starts 25 years ago with the evidence that CSC is a
subpopulation of tumor cells that have renewal ability and can differentiate into several …

A spotlight has been shone on endoglin in recent years due to that fact of its potential to
serve as both a reliable disease biomarker and a therapeutic target. Indeed, endoglin has …

Background The anti-tumor properties of cannabinoids have been investigated in many in
vitro and in vivo studies. Many of these anti-tumor effects are mediated via cannabinoid …