Parkinson disease (PD) is a progressive disorder characterized by dopaminergic
neurodegeneration in the brain. The development of parkinsonism is preceded by a long …

A major challenge in Parkinson's disease is the variability in symptoms and rates of
progression, underpinned by heterogeneity of pathological processes. Biomarkers are …

Iron has a long and storied history in Parkinson disease and related disorders. This
essential micronutrient is critical for normal brain function, but abnormal brain iron …

Disruptions to dopamine and noradrenergic neurotransmission are noted in several
neurodegenerative and psychiatric disorders. Neuromelanin-sensitive (NM)-MRI offers a …

MRI has been used to develop biomarkers for movement disorders such as Parkinson
disease (PD) and other neurodegenerative disorders with parkinsonism such as progressive …

Iron accumulation in the brain is a common feature of many neurodegenerative diseases. Its
involvement spans across the main proteinopathies involving tau, amyloid-beta, alpha …

Parkinson's disease (PD) diagnosis based on magnetic resonance imaging (MRI) is still
challenging clinically. Quantitative susceptibility maps (QSM) can potentially provide …

Neuromelanin (NM) loss in substantia nigra pars compacta (SNc) and locus coeruleus (LC)
reflects neuronal death in Parkinson's disease (PD). Since genetically-determined PD …

Parkinson's disease (PD) is a prevalent neurodegenerative disorder that presents a
diagnostic challenge due to symptom overlap with other disorders. Neuromelanin (NM) …

Background and purpose Early diagnosis of Parkinson's disease (PD) is still a clinical
challenge. Most previous studies using manual or semi-automated methods for segmenting …