Impaired dopamine release in Parkinson's disease

KML Cramb, D Beccano-Kelly, SJ Cragg… - Brain, 2023 - academic.oup.com
Parkinson's disease is the second most common neurodegenerative disease and yet the
early pathophysiological events of the condition and sequences of dysfunction remain …

Parkinson's disease: from pathogenesis to pharmacogenomics

R Cacabelos - International journal of molecular sciences, 2017 - mdpi.com
Parkinson's disease (PD) is the second most important age-related neurodegenerative
disorder in developed societies, after Alzheimer's disease, with a prevalence ranging from …

Employing conductive metal–organic frameworks for voltammetric detection of neurochemicals

M Ko, L Mendecki, AM Eagleton… - Journal of the …, 2020 - ACS Publications
This paper describes the first implementation of an array of two-dimensional (2D) layered
conductive metal–organic frameworks (MOFs) as drop-casted film electrodes that facilitate …

Dopamine, oxidative stress and protein–quinone modifications in Parkinson's and other neurodegenerative diseases

E Monzani, S Nicolis, S Dell'Acqua… - Angewandte Chemie …, 2019 - Wiley Online Library
Dopamine (DA) is the most important catecholamine in the brain, as it is the most abundant
and the precursor of other neurotransmitters. Degeneration of nigrostriatal neurons of …

Adrenal aging and its implications on stress responsiveness in humans

A Yiallouris, C Tsioutis, E Agapidaki, M Zafeiri… - Frontiers in …, 2019 - frontiersin.org
Normal aging results in subtle changes both in ACTH and cortisol secretion. Most notable is
the general increase in mean daily serum cortisol levels in the elderly, without a noteworthy …

Promising drug targets and associated therapeutic interventions in Parkinson's disease

SN Rai, P Singh, R Varshney… - Neural regeneration …, 2021 - journals.lww.com
Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the
availability of symptomatic treatments, response towards the health of PD patients remains …

NIR biosensing of neurotransmitters in stem cell‐derived neural interface using advanced core–shell upconversion nanoparticles

H Rabie, Y Zhang, N Pasquale, MJ Lagos… - Advanced …, 2019 - Wiley Online Library
Nondestructive neurotransmitter detection and real‐time monitoring of stem cell
differentiation are both of great significance in the field of neurodegenerative disease and …

Mass spectrometry–based proteomics analysis of human substantia nigra from Parkinson's disease patients identifies multiple pathways potentially involved in the …

Y Jang, O Pletnikova, JC Troncoso, AY Pantelyat… - Molecular & Cellular …, 2023 - ASBMB
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder
characterized by the loss of dopaminergic neurons in the substantia nigra (SN) of the brain …

Single-cell sequencing reveals suppressive transcriptional programs regulated by MIS/AMH in neonatal ovaries

MC Meinsohn, HD Saatcioglu, L Wei… - Proceedings of the …, 2021 - National Acad Sciences
Müllerian inhibiting substance (MIS/AMH), produced by granulosa cells of growing follicles,
is an important regulator of folliculogenesis and follicle development. Treatment with …

Diabetes causes dysfunctional dopamine neurotransmission favoring nigrostriatal degeneration in mice

I Pérez‐Taboada, S Alberquilla, ED Martín… - Movement …, 2020 - Wiley Online Library
Background Numerous studies indicate an association between neurodegenerative and
metabolic diseases. Although still a matter of debate, growing evidence from …