Chronic inflammation in the kidneys and vascular wall is a major contributor to hypertension.
However, the stimuli and cellular mechanisms responsible for such inflammatory responses …

Apocynin is a naturally occurring methoxy‐substituted catechol, experimentally used as an
inhibitor of NADPH‐oxidase. It can decrease the production of superoxide (O 2−) from …

The superoxide generating enzyme NADPH oxidase has received much attention as a
major cause of oxidative stress underlying vascular disease. However, there is increasing …

Nitric oxide (NO) plays a pivotal role in the maintenance of cardiovascular homeostasis. A
reduction in the bioavailability of endogenous NO, manifest as a decrease in the production …

Vascular inflammation has traditionally been thought to be initiated at the luminal surface
and progress through the media toward the adventitial layer. In recent years, however …

Objective—Transdifferentiation of adventitial fibroblasts (AFs) into myofibroblasts plays a
critical role during the vascular remodeling that occurs during atherosclerosis, restenosis …

Cis-diamminedichloroplatinum (II)(cisplatin) is an effective chemotherapeutic agent
successfully used in the treatment of a wide range of tumors; however, nephrotoxicity has …

Meijles and Pagano Nox and Inflammation in the Vascular Adventitia 15 in vascular
pathophysiology because of their signaling roles in a range of cellular processes, including …

Purpose.: Theproliferation of new blood vessels in the retina is a leading cause of vision
impairment. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) is …

Mercury increases the risk of cardiovascular disease and oxidative stress and alters
vascular reactivity. This metal elicits endothelial dysfunction causing decreased NO …