Synthetic protein condensates for cellular and metabolic engineering
Protein condensates are distinct structures assembled in living cells that concentrate
molecules via phase separation in a confined subcellular compartment. In the past decade …
molecules via phase separation in a confined subcellular compartment. In the past decade …
P450-driven plastic-degrading synthetic bacteria
Plastic contamination currently threatens a wide variety of ecosystems and presents
damaging repercussions and negative consequences for many wildlife species. Sustainable …
damaging repercussions and negative consequences for many wildlife species. Sustainable …
Engineered Artificial Membraneless Organelles in Saccharomyces cerevisiae To Enhance Chemical Production
P Zhou, H Liu, X Meng, H Zuo, M Qi… - Angewandte Chemie …, 2023 - Wiley Online Library
Microbial cell factories provide a green and sustainable opportunity to produce value‐added
products from renewable feedstock. However, the leakage of toxic or volatile intermediates …
products from renewable feedstock. However, the leakage of toxic or volatile intermediates …
Engineering status of protein for improving microbial cell factories
With the development of metabolic engineering and synthetic biology, microbial cell
factories (MCFs) have provided an efficient and sustainable method to synthesize a series of …
factories (MCFs) have provided an efficient and sustainable method to synthesize a series of …
Outer membrane vesicles catabolize lignin-derived aromatic compounds in Pseudomonas putida KT2440
Lignin is an abundant and recalcitrant component of plant cell walls. While lignin
degradation in nature is typically attributed to fungi, growing evidence suggests that bacteria …
degradation in nature is typically attributed to fungi, growing evidence suggests that bacteria …
A “push-pull-restrain” strategy to improve citronellol production in Saccharomyces cerevisiae
G Jiang, M Yao, Y Wang, W Xiao, Y Yuan - Metabolic Engineering, 2021 - Elsevier
Microbial production of monoterpenes has attracted increasing attention in recent years. Up
to date, there are only few reports on the biosynthesis of the monoterpene alcohol citronellol …
to date, there are only few reports on the biosynthesis of the monoterpene alcohol citronellol …
Reductive cytochrome P450 reactions and their potential role in bioremediation
JBYH Behrendorff - Frontiers in Microbiology, 2021 - frontiersin.org
Cytochrome P450 enzymes, or P450s, are haem monooxygenases renowned for their ability
to insert one atom from molecular oxygen into an exceptionally broad range of substrates …
to insert one atom from molecular oxygen into an exceptionally broad range of substrates …
Emerging strategies for modifying lignin chemistry to enhance biological lignin valorization
Biological lignin valorization represents a promising approach contributing to sustainable
and economic biorefineries. The low level of valuable lignin‐derived products remains a …
and economic biorefineries. The low level of valuable lignin‐derived products remains a …
Synthetic protein scaffolds for the colocalisation of co-acting enzymes
J Vanderstraeten, Y Briers - Biotechnology Advances, 2020 - Elsevier
Nature relies on complexes of colocated enzymes to efficiently perform multiple catalytic
steps. Such enzyme colocalisation promotes substrate channelling, enhances the activity of …
steps. Such enzyme colocalisation promotes substrate channelling, enhances the activity of …
De novo design of a reversible phosphorylation-dependent switch for membrane targeting
L Harrington, JM Fletcher, T Heermann… - Nature …, 2021 - nature.com
Modules that switch protein-protein interactions on and off are essential to develop synthetic
biology; for example, to construct orthogonal signaling pathways, to control artificial protein …
biology; for example, to construct orthogonal signaling pathways, to control artificial protein …