Iron deficiency and immune activation are the two most frequent causes of anemia, both of
which are based on disturbances of iron homeostasis. Iron deficiency anemia results from a …

Macrophages reside in virtually every organ. First arising during embryogenesis,
macrophages replenish themselves in the adult through a combination of self-renewal and …

Hepcidin is an antimicrobial peptide secreted by the liver during inflammation that plays a
central role in mammalian iron homeostasis. Here we demonstrate the endogenous …

Iron is an important cofactor required for a number of essential cell functions and hence is a
vital nutrient. However, iron can also be dangerous as a catalyst of free radical reactions …

Immunosuppression mediated by regulatory T cells (Tregs) is a key facilitator of tumor
immune evasion, but the source of these Tregs and their contribution to human cancer …

The hemochromatosis gene HFE was discovered in 1996, more than a century after clinical
and pathologic manifestations of hemochromatosis were reported. Linked to the major …

The proinflammatory cytokine TNF has a pivotal role in liver pathophysiology because it
holds the capacity to induce both hepatocyte cell death and hepatocyte proliferation. This …

Patients with chronic hepatitis C frequently have serum and hepatic iron overload, but the
mechanism is unknown. Recently identified hepcidin, exclusively synthesized in the liver, is …

The advent of the genetics era has profoundly changed the way we look at iron related
diseases, particularly hemochromatosis. New discoveries have challenged historical …

Body iron is involved in various vital functions. Its uptake in the intestine is regulated by
hepcidin, a bioactive peptide originally identified in plasma and urine and subsequently in …