Review of local extravascular delivery systems for chemotherapeutic agents in small animals and horses

M Risselada, DB Worth - The Canadian Veterinary Journal, 2023 - ingentaconnect.com
Background Tumors of various sizes and locations can create a treatment dilemma in
achieving adequate surgical margins when sufficient free tissue is not available for closure …

[HTML][HTML] Amikacin in 30% poloxamer 407 is a versatile local therapy with method of application and outcome documented in 29 dogs

M Risselada, KE Spies, SY Kim - Journal of the American …, 2024 - Am Vet Med Assoc
OBJECTIVE To report the clinical use, adverse events, and outcomes after using amikacin in
30% poloxamer 407 (amikacin-P407) during open wound management or in a closed …

Platinum measurements in Dulbecco's phosphate-buffered saline are lower than in plasma and can be sampled with ultrafiltration probes in vitro

M Risselada, R McCain - American Journal of Veterinary …, 2024 - Am Vet Med Assoc
OBJECTIVE To compare the influence of fluid on carboplatin elution, and assess the
feasibility of ultrafiltration (UF) probe sampling SAMPLE 20 samples of 5 mg carboplatin in …

Bead size has a greater effect on in vitro elution from antimicrobial-impregnated calcium sulfate beads than drug concentration

RS Olsen, DM Sawyere, JL Davis… - American Journal of …, 2023 - Am Vet Med Assoc
OBJECTIVE To compare the elution characteristics of amikacin-impregnated calcium sulfate
(CaSO 4) beads based on different drug concentrations and bead size configurations …

Repeatability of in vitro carboplatin elution from carboplatin‐impregnated calcium sulfate hemihydrate beads made in a clinic setting

DB Worth, M Risselada, BR Cooper… - Veterinary …, 2020 - Wiley Online Library
Objective To evaluate the intra‐lot and inter‐lot consistency and total carboplatin elution
over 25 days from carboplatin‐impregnated calcium sulfate hemihydrate (C‐I CSH) beads …

Characterization of long-term elution of platinum from carboplatin-impregnated calcium sulfate hemihydrate beads in vitro by two distinct sample collection methods

RJ Tulipan, H Phillips, LD Garrett… - American journal of …, 2017 - Am Vet Med Assoc
OBJECTIVE To characterize long-term elution of platinum from carboplatin-impregnated
calcium sulfate hemihydrate (CI-CSH) beads in vitro by comparing 2 distinct sample …

Pharmacokinetics of platinum and safety evaluation of carboplatin‐impregnated calcium sulfate hemihydrate beads after implantation in healthy cats

EA Maxwell, H Phillips, SC Clark‐Price… - Veterinary …, 2020 - Wiley Online Library
Objective To evaluate the pharmacokinetics (PK) of platinum (Pt) and safety of carboplatin‐
impregnated calcium sulfate hemihydrate (C‐I CSH) beads after implantation in healthy cats …

Evaluation of bioabsorbable calcium sulfate hemihydrate beads for local delivery of carboplatin

M Traverson, CE Stewart, MG Papich - Plos one, 2020 - journals.plos.org
The objectives of this study were to evaluate a novel kit of resorbable calcium sulfate beads
marketed specifically for use in veterinary medicine and generally used for local delivery of …

Pharmacokinetic and safety assessment of carboplatin‐impregnated calcium sulfate hemihydrate beads in eight rats

B Belda, J Ramos‐Vara, KM Messenger… - Veterinary …, 2021 - Wiley Online Library
Objective Evaluate local tissue toxicity and plasma platinum (Pt) in vivo after subcutaneous
implantation of carboplatin‐impregnated calcium sulfate hemihydrate (CI‐CSH) beads …

Simulation of spatial diffusion of platinum from carboplatin-impregnated calcium sulfate hemihydrate beads by use of an agarose gelatin tissue phantom

H Phillips, EA Maxwell, DJ Schaeffer… - American journal of …, 2018 - Am Vet Med Assoc
OBJECTIVE To characterize spatial release of platinum from carboplatin-impregnated
calcium sulfate hemihydrate (CI-CSH) beads by use of an agarose tissue phantom. SAMPLE …