Uncovering the mechanism (s) of action of deep brain stimulation: activation, inhibition, or both
CC McIntyre, M Savasta, L Kerkerian-Le Goff… - Clinical …, 2004 - Elsevier
High-frequency deep brain stimulation (DBS) of the thalamus or basal ganglia represents an
effective clinical technique for the treatment of several medically refractory movement …
effective clinical technique for the treatment of several medically refractory movement …
How does deep brain stimulation work? Present understanding and future questions
High-frequency deep brain stimulation (DBS) of the thalamus or basal ganglia represents an
effective clinical technique for the treatment of several medically refractory movement …
effective clinical technique for the treatment of several medically refractory movement …
The mechanisms of action of deep brain stimulation and ideas for the future development
Deep brain stimulation (DBS) has been used as a treatment of movement disorders such as
Parkinson's disease, dystonia, and essential tremor for over twenty years, and is a promising …
Parkinson's disease, dystonia, and essential tremor for over twenty years, and is a promising …
Expanding the repertoire of L-DOPA's actions: A comprehensive review of its functional neurochemistry
P De Deurwaerdère, G Di Giovanni, MJ Millan - Progress in neurobiology, 2017 - Elsevier
Though a multi-facetted disorder, Parkinson's disease is prototypically characterized by
neurodegeneration of nigrostriatal dopaminergic neurons of the substantia nigra pars …
neurodegeneration of nigrostriatal dopaminergic neurons of the substantia nigra pars …
High-frequency stimulation in Parkinson's disease: more or less?
Deep-brain stimulation at high frequency is now considered the most effective neurosurgical
therapy for movement disorders. An electrode is chronically implanted in a particular area of …
therapy for movement disorders. An electrode is chronically implanted in a particular area of …
Latest view on the mechanism of action of deep brain stimulation
How does deep brain stimulation (DBS) applied at high frequency (100 Hz and above, HFS)
in diverse points of cortico‐basal ganglia thalamo‐cortical loops alleviate symptoms of …
in diverse points of cortico‐basal ganglia thalamo‐cortical loops alleviate symptoms of …
Deep brain stimulation in neurological diseases and experimental models: from molecule to complex behavior
P Gubellini, P Salin, L Kerkerian-Le Goff… - Progress in …, 2009 - Elsevier
Deep brain stimulation (DBS) has proven to be capable of providing significant benefits for
several neuropathologies. It is highly effective in reducing the motor symptoms of …
several neuropathologies. It is highly effective in reducing the motor symptoms of …
Subthalamic nucleus deep brain stimulation is neuroprotective in the A53T α‐synuclein Parkinson's disease rat model
T Musacchio, M Rebenstorff, F Fluri… - Annals of …, 2017 - Wiley Online Library
Objective Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly
effective symptomatic therapy for motor deficits in Parkinson's disease (PD). An additional …
effective symptomatic therapy for motor deficits in Parkinson's disease (PD). An additional …
Obsessive-compulsive disorder: Insights from animal models
Research with animal models of obsessive-compulsive disorder (OCD) shows the
following:(1) Optogenetic studies in mice provide evidence for a plausible cause-effect …
following:(1) Optogenetic studies in mice provide evidence for a plausible cause-effect …
Disrupting neuronal transmission: mechanism of DBS?
S Chiken, A Nambu - Frontiers in systems neuroscience, 2014 - frontiersin.org
Applying high-frequency stimulation (HFS) to deep brain structure, known as deep brain
stimulation (DBS), has now been recognized an effective therapeutic option for a wide range …
stimulation (DBS), has now been recognized an effective therapeutic option for a wide range …