Aminoacyl-tRNA synthetases as therapeutic targets
Aminoacyl-tRNA synthetases (ARSs) are essential enzymes for protein synthesis with
evolutionarily conserved enzymatic mechanisms. Despite their similarity across organisms …
evolutionarily conserved enzymatic mechanisms. Despite their similarity across organisms …
Roles of aminoacyl-tRNA synthetases in cancer
Z Zhou, B Sun, A Nie, D Yu, M Bian - Frontiers in cell and …, 2020 - frontiersin.org
Aminoacyl-tRNA synthetases (ARSs) catalyze the ligation of amino acids to their cognate
transfer RNAs (tRNAs), thus playing an important role in protein synthesis. In eukaryotic …
transfer RNAs (tRNAs), thus playing an important role in protein synthesis. In eukaryotic …
Disease association and therapeutic routes of aminoacyl-tRNA synthetases
I Yoon, U Kim, J Choi, S Kim - Trends in Molecular Medicine, 2023 - cell.com
Aminoacyl-tRNA synthetases (ARSs) are enzymes that catalyze the ligation of amino acids
to tRNAs for translation. Beyond their traditional role in translation, ARSs have acquired …
to tRNAs for translation. Beyond their traditional role in translation, ARSs have acquired …
Roles of aminoacyl-tRNA synthetase-interacting multi-functional proteins in physiology and cancer
Z Zhou, B Sun, S Huang, D Yu, X Zhang - Cell Death & Disease, 2020 - nature.com
Aminoacyl-tRNA synthetases (ARSs) are an important class of enzymes with an
evolutionarily conserved mechanism for protein synthesis. In higher eukaryotic systems …
evolutionarily conserved mechanism for protein synthesis. In higher eukaryotic systems …
Roles of tRNA metabolism in aging and lifespan
Z Zhou, B Sun, D Yu, M Bian - Cell Death & Disease, 2021 - nature.com
Transfer RNAs (tRNAs) mainly function as adapter molecules that decode messenger RNAs
(mRNAs) during protein translation by delivering amino acids to the ribosome. Traditionally …
(mRNAs) during protein translation by delivering amino acids to the ribosome. Traditionally …
KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition
Y Zhong, J Yang, WW Xu, Y Wang, CC Zheng, B Li… - Oncogene, 2017 - nature.com
Cell cycle dysregulation leads to uncontrolled cell proliferation and tumorigenesis.
Understanding the molecular mechanisms underlying cell cycle progression can provide …
Understanding the molecular mechanisms underlying cell cycle progression can provide …
Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development
S Lim, HY Cho, DG Kim, Y Roh, SY Son… - Nature chemical …, 2020 - nature.com
A tumorigenic factor, AIMP2 lacking exon 2 (AIMP2-DX2), is often upregulated in many
cancers. However, how its cellular level is determined is not understood. Here, we report …
cancers. However, how its cellular level is determined is not understood. Here, we report …
Aminoacyl‐tRNA synthetase–a molecular multitasker
Aminoacyl‐tRNA synthetases (AaRSs) are valuable “housekeeping” enzymes that ensure
the accurate transmission of genetic information in living cells, where they aminoacylated …
the accurate transmission of genetic information in living cells, where they aminoacylated …
SIRT7 promotes lung cancer progression by destabilizing the tumor suppressor ARF
P Kumari, S Tarighi, E Fuchshuber… - Proceedings of the …, 2024 - National Acad Sciences
Sirtuin 7 (SIRT7) is a member of the mammalian family of nicotinamide adenine dinucleotide
(NAD+)-dependent histone/protein deacetylases, known as sirtuins. It acts as a potent …
(NAD+)-dependent histone/protein deacetylases, known as sirtuins. It acts as a potent …
Synthesis and discovery of the first potent proteolysis targeting chimaera (PROTAC) degrader of AIMP2-DX2 as a lung cancer drug
BR Lee, DG Kim, A Lee, YM Kim, L Cui… - Journal of enzyme …, 2023 - Taylor & Francis
ARS-interacting multifunctional proteins 2 (AIMP2) is known to be a powerful tumour
suppressor. However, the target AIMP2-DX2, AIMP2-lacking exon 2, is often detected in …
suppressor. However, the target AIMP2-DX2, AIMP2-lacking exon 2, is often detected in …