Naegleria fowleri has generated tremendous media attention over the last 5 years due to
several high-profile cases. Several of these cases were followed very closely by the general …

AIMS: Tuberculosis and mental illness share common risk factors including homelessness,
HIV positive serology, alcohol/substance abuse and migrant status leading to frequent …

Background: Rifampin is a potent inducer of both cytochrome P-450 oxidative enzymes and
the P-glycoprotein transport system. Among numerous well documented, clinically …

This is a comprehensive review of the literature on drug interactions (DIs) between atypical
antipsychotics and anti-infective agents that focuses on those DIs with the potential to be …

Many genetic variants in drug metabolizing enzymes and transporters have been shown to
be relevant for treating psychiatric disorders. Associations are strong enough to feature on …

The polymyxins are increasingly important because of the continued emergence of
multidrug resistant (MDR) gram-negative organisms, such as strains of Pseudomonas …

Like any other drug, antimicrobial drugs are prone to pharmacokinetic drug interactions.
These drug interactions are a major concern in clinical practice as they may have an effect …

The fish embryo acute toxicity (FET) test with the zebrafish (Danio rerio) embryo according to
OECD TG 236 was originally developed as an alternative test method for acute fish toxicity …

Risperidone is metabolized to its active metabolite, 9-hydroxyrisperidone, mainly by the
cytochrome P450 enzymes CYP2D6 and 3A4. Its antipsychotic effect is assumed to be …

The cytochrome P450 2D6 (CYP2D6) genotype is the single most important determinant of
CYP2D6 activity as well as interindividual and interpopulation variability in CYP2D6 activity …