Amorphous solid dispersions are an increasingly important formulation approach to improve
the dissolution rate and apparent solubility of poorly water soluble compounds. Due to their …

This compendium completes a previous report published in 2016 [2016ACR/CHI] on phase
change enthalpies. Paper I of this compendium includes over 6600 organic compounds …

The objective of the present study was to determine the solid state solubility and miscibility of
naproxen in poly (vinylpyrrolidone)(PVP) and the mutual interaction using the standard …

The aim of this work was to develop a method which uses experimentally obtainable data to
predict the complete phase diagram of drug–polymer solid dispersion systems, for the first …

We investigated the effect of polymer composition on nifedipine (NIF) dissolution through
molecular-level characterization of NIF/hypromellose (HPMC)/Eudragit S (EUD-S) ternary …

Nanofibrous systems are attracting increasing interest as a means of drug delivery, although
a significant limitation to this approach has been manufacture on a scale commensurate with …

Co-amorphous mixtures have rarely been formulated as oral dosage forms, even though
they have been shown to stabilize amorphous drugs in the solid state and enhance the …

Thermodynamic parameters of fusion define the solubility and stability of the crystalline
materials and thus are important in the field of pharmaceutics. However, determining these …

Knowledge of the molecular structures of solid dispersions is vital, yet, despite thousands of
reports in this area, it remains unclear. The aim of this research is to investigate the …

The physical stability of amorphous solid dispersions (ASD) of active pharmaceutical
ingredients (APIs) of high glass forming ability (GFA class III) is generally expected to be …