Abstract The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs)
enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that …

The extracellular matrix (ECM) is a complex network of proteins, glycoproteins,
proteoglycans, and polysaccharides. Through multiple interactions with each other and the …

Together with seven ADAMTS-like proteins, the 19 mammalian ADAMTS proteases
constitute a superfamily. ADAMTS proteases are secreted zinc metalloproteases whose …

Proteolytic processes in the extracellular matrix are a major influence on cell adhesion,
migration, survival, differentiation and proliferation. The syndecan cell‐surface …

The four syndecans identified in mammals are membrane proteoglycans that play major
roles in regulating cell behavior, cell signaling, and cell‐matrix interactions. The membrane …

The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family
comprises 19 proteases that regulate the structure and function of extracellular proteins in …

Heparan sulfate (HS) proteoglycans at cell surfaces and in the extracellular matrix of most
animal tissues are essential in development and homeostasis, and variously implicated in …

The mammalian ADAMTS superfamily comprises 19 secreted metalloproteinases and 7
ADAMTS-like proteins, each the product of a distinct gene. Thus far, all appear to be relevant …

Gastric cancer is a dominating cause of cancer-associated mortality with limited therapeutic
options. Here, we show that syndecan-4 (SDC4), a transmembrane proteoglycan, is highly …

Proteoglycans are composite molecules comprising a protein backbone, ie, the core protein,
with covalently attached glycosaminoglycan chains of distinct chemical types. Most …