Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

Covering: 2000 to 2017 Cytochrome P450 enzymes (P450s) are the most versatile
biocatalysts in nature. The catalytic competence of these extraordinary hemoproteins is …

Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …

Hydroxytryptophan serves as a chemical precursor to a variety of bioactive specialized
metabolites, including the human neurotransmitter serotonin and the hormone melatonin …

Covering: 2008 up to 2019 The forces of biochemical adaptive evolution operate at the level
of genes, manifesting in complex phenotypes and the global biodiversity of proteins and …

Indole diketopiperazine alkaloids are secondary metabolites of microorganisms that are
widely distributed in filamentous fungi, especially in the genera Aspergillus and Penicillium …

Authored by leading experts in the enzymology of natural product biosynthesis, this textbook
provides a thorough description of the types of natural products, the biosynthetic pathways …

Covering: up to 2014 This review provides a summary of recent research advances in
elucidating the biosynthesis of fungal indole alkaloids. The different strategies used to …

Covering: up to 2018 α-Ketoglutarate (αKG, also known as 2-oxoglutarate)-dependent
mononuclear non-haem iron (αKG-NHFe) enzymes catalyze a wide range of biochemical …

Psychoactive natural products play an integral role in the modern world. The tremendous
structural complexity displayed by such molecules confers diverse biological activities of …