Cannabinoids as anticancer drugs: current status of preclinical research

B Hinz, R Ramer - British journal of cancer, 2022 - nature.com
Drugs that target the endocannabinoid system are of interest as pharmacological options to
combat cancer and to improve the life quality of cancer patients. From this perspective …

Cannabidiol: State of the art and new challenges for therapeutic applications

S Pisanti, AM Malfitano, E Ciaglia, A Lamberti… - Pharmacology & …, 2017 - Elsevier
Over the past years, several lines of evidence support a therapeutic potential of Cannabis
derivatives and in particular phytocannabinoids. Δ 9-THC and cannabidiol (CBD) are the …

The role of hypoxia in glioblastoma invasion

AR Monteiro, R Hill, GJ Pilkington, PA Madureira - Cells, 2017 - mdpi.com
Glioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly
type of primary malignant brain tumor, with a patient's median survival rate ranging from 15 …

[HTML][HTML] Anticancer mechanisms of cannabinoids

G Velasco, C Sánchez, M Guzmán - Current Oncology, 2016 - ncbi.nlm.nih.gov
In addition to the well-known palliative effects of cannabinoids on some cancer-associated
symptoms, a large body of evidence shows that these molecules can decrease tumour …

The endocannabinoid system: A target for cancer treatment

C Laezza, C Pagano, G Navarra, O Pastorino… - International journal of …, 2020 - mdpi.com
In recent years, the endocannabinoid system has received great interest as a potential
therapeutic target in numerous pathological conditions. Cannabinoids have shown an …

The ID proteins: master regulators of cancer stem cells and tumour aggressiveness

A Lasorella, R Benezra, A Iavarone - Nature Reviews Cancer, 2014 - nature.com
Inhibitor of DNA binding (ID) proteins are transcriptional regulators that control the timing of
cell fate determination and differentiation in stem and progenitor cells during normal …

Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma

E Singer, J Judkins, N Salomonis, L Matlaf… - Cell death & …, 2015 - nature.com
Glioblastoma (GBM) resistance to therapy is the most common cause of tumor recurrence,
which is ultimately fatal in 90% of the patients 5 years after initial diagnosis. A sub …

[HTML][HTML] Cannabinoids as therapeutic agents in cancer: current status and future implications

B Chakravarti, J Ravi, RK Ganju - Oncotarget, 2014 - ncbi.nlm.nih.gov
The pharmacological importance of cannabinoids has been in study for several years.
Cannabinoids comprise of (a) the active compounds of the Cannabis sativa plant,(b) …

Anti‐tumour actions of cannabinoids

B Hinz, R Ramer - British journal of pharmacology, 2019 - Wiley Online Library
The endocannabinoid system has emerged as an important target for the treatment of many
diverse diseases. In addition to the well‐established palliative effects of cannabinoids in …

Glioblastoma stem-like cells: at the root of tumor recurrence and a therapeutic target

M Jackson, F Hassiotou, A Nowak - Carcinogenesis, 2015 - academic.oup.com
Glioblastoma is the most common and most aggressive primary brain malignancy. The
current initial standard of care consists of maximal safe surgical resection followed by radical …