FLT3 mutations are one of the most common findings in acute myeloid leukemia (AML).
FLT3 inhibitors have been in active clinical development. Midostaurin as the first-in-class …

Acute myeloid leukemia (AML) is a highly aggressive hematological malignancy with
complex heterogenous genetic and biological nature. Thus, prognostic prediction and …

FMS-like tyrosine kinase 3 (FLT3) enzyme overexpression and mutations are the most
common molecular abnormalities associated with acute myeloid leukemia (AML). In …

The mitogen-activated protein kinase (MAPK) signaling pathway member T-LAK cell–
originated protein kinase/PDZ-binding kinase (TOPK/PBK) is closely involved in …

Acute myeloid leukemia (AML) is a malignant disease characterized by abnormal growth
and differentiation of hematopoietic stem cells. Although the pathogenesis has not been fully …

Rho-associated protein kinases (ROCKs) are ubiquitously expressed in most adult tissues,
and are involved in modulating the cytoskeleton, protein synthesis and degradation …

Uncontrolled proliferative signals and cell cycle dysregulation due to genomic or functional
alterations are important drivers of the expansion of undifferentiated blast cells in acute …

The 3 H-pyrazolo [4, 3-f] quinoline moiety has been recently shown to be a privileged kinase
inhibitor core with potent activities against acute myeloid leukemia (AML) cell lines in vitro …

Multicomponent reaction (MCR) is often used to rapidly assemble complex compounds for
drug screening. Povarov MCR has been used to prepare a new library containing tetrahydro …

The cGAS–STING axis plays an important role in protecting higher organisms against
invading pathogens or cancer by promoting the production of cytokines and interferons …