Academic and industrial groups worldwide have reported technological advances in
exosome-based cancer diagnosis and prognosis. However, the potential translation of these …

Mesenchymal stem cells (MSCs) represent a heterogeneous cellular population responsible
for the support, maintenance, and regulation of normal hematopoietic stem cells (HSCs). In …

Repair of large bone defects represents a major challenge for orthopedic surgeons. The
newly formed microvessels inside grafts play a crucial role in successful bone tissue …

Compared to embryonic and induced pluripotent stem cells, mesenchymal stem/stromal
cells (MSCs) have made their presence felt with good therapeutic promise and safety profile …

Mesenchymal stromal cells (MSCs) are key elements in the bone marrow (BM) niche where
they interact with hematopoietic stem progenitor cells (HSPCs) by offering physical support …

Currently, bone defect repair is still an intractable clinical problem. Numerous treatments
have been performed, but their clinical results are unsatisfactory. As a key element of cell …

Acute myeloid leukemias (AML) are clonal disorders of hematopoietic progenitor cells which
are characterized by relevant heterogeneity in terms of phenotypic, genotypic, and clinical …

Systemic sclerosis (SSc) is an intractable autoimmune disease with unmet medical needs.
Conventional immunosuppressive therapies have modest efficacy and obvious side effects …

Bone marrow mesenchymal stromal cells (MSCs) play a crucial role in the regulation of
hematopoiesis. These cells affect the process through direct cell–cell contact, as well as …

Autoimmune conditions, such as rheumatoid arthritis, are characterised by a loss of immune
tolerance, whereby the immune cells attack self-antigens causing pain and inflammation …