Applied machine learning as a driver for polymeric biomaterials design
SM McDonald, EK Augustine, Q Lanners… - Nature …, 2023 - nature.com
Polymers are ubiquitous to almost every aspect of modern society and their use in medical
products is similarly pervasive. Despite this, the diversity in commercial polymers used in …
products is similarly pervasive. Despite this, the diversity in commercial polymers used in …
Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres—A review
PLGA microspheres are widely studied for controlled release drug delivery applications, and
many models have been proposed to describe PLGA degradation and erosion and drug …
many models have been proposed to describe PLGA degradation and erosion and drug …
Potential roles of the glass transition temperature of PLGA microparticles in drug release kinetics
Poly (lactic-co-glycolic acid)(PLGA) has been used for long-acting injectable drug delivery
systems for more than 30 years. The factors affecting the properties of PLGA formulations …
systems for more than 30 years. The factors affecting the properties of PLGA formulations …
Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes
AJ Glowacki, S Yoshizawa… - Proceedings of the …, 2013 - National Acad Sciences
The hallmark of periodontal disease is the progressive destruction of gingival soft tissue and
alveolar bone, which is initiated by inflammation in response to an invasive and persistent …
alveolar bone, which is initiated by inflammation in response to an invasive and persistent …
Biomimetic delivery with micro‐and nanoparticles
SC Balmert, SR Little - Advanced materials, 2012 - Wiley Online Library
The nascent field of biomimetic delivery with micro‐and nanoparticles (MNP) has advanced
considerably in recent years. Drawing inspiration from the ways that cells communicate in …
considerably in recent years. Drawing inspiration from the ways that cells communicate in …
Reverse engineering the Ozurdex dexamethasone intravitreal implant
Ozurdex is a biodegradable implant formulated for sustained-release delivery of the
corticosteroid dexamethasone to the posterior segment of the eye. The small, rod-shaped …
corticosteroid dexamethasone to the posterior segment of the eye. The small, rod-shaped …
Modeling of the burst release from PLGA micro-and nanoparticles as function of physicochemical parameters and formulation characteristics
CR de Azevedo, M von Stosch, MS Costa… - International journal of …, 2017 - Elsevier
A substantial drug release from poly (lactic-co-glycolic) acid (PLGA) micro-and nanoparticles
can occur in the first hours of immersion, which is referred to as burst release. A strong burst …
can occur in the first hours of immersion, which is referred to as burst release. A strong burst …
The impact of monomer sequence and stereochemistry on the swelling and erosion of biodegradable poly (lactic-co-glycolic acid) matrices
MA Washington, DJ Swiner, KR Bell, MV Fedorchak… - Biomaterials, 2017 - Elsevier
Monomer sequence is demonstrated to be a primary factor in determining the hydrolytic
degradation profile of poly (lactic-co-glycolic acid) s (PLGAs). Although many approaches …
degradation profile of poly (lactic-co-glycolic acid) s (PLGAs). Although many approaches …
Drug release mechanisms of high-drug-load, melt-extruded dexamethasone intravitreal implants
Ozurdex is an FDA–approved sustained-release, biodegradable implant formulated to
deliver the corticosteroid dexamethasone to the posterior segment of the eye for up to 6 …
deliver the corticosteroid dexamethasone to the posterior segment of the eye for up to 6 …
Monomer sequence in PLGA microparticles: Effects on acidic microclimates and in vivo inflammatory response
MA Washington, SC Balmert, MV Fedorchak, SR Little… - Acta Biomaterialia, 2018 - Elsevier
Controlling the backbone architecture of poly (lactic-co-glycolic acid) s (PLGAs) is
demonstrated to have a strong influence on the production and release of acidic …
demonstrated to have a strong influence on the production and release of acidic …