The average lifelong rate of developing a new primary lung cancer approximates 1% and
6% per year after radical therapy for non–small-cell lung cancer and small cell lung cancer …

Purpose To compare the mutational and copy number profiles of primary and metastatic
colorectal carcinomas (CRCs) using both unpaired and paired samples derived from …

Clonal analysis of tumour sequencing data enables the evaluation of the relationship of
histologically distinct synchronous lesions, such as co-existing benign areas, and temporally …

Purpose: The tumor genomic copy number profile is of prognostic significance in
neuroblastoma patients. We have studied the genomic copy number profile of cell-free DNA …

Purpose: In cases of multiple non–small cell lung cancer, clinicians must decide whether
patients have independent tumors or metastases and tailor treatment accordingly. Decisions …

BACKGROUND: Since multiple lung cancer treatment strategies differ, it is essential for
clinicians to be able to distinguish between separate primary lesions and metastasis. In the …

Purpose: A gene expression signature, predictive for local recurrence after breast-
conserving treatment, has previously been identified from a series of 165 young patients …

Background Breast-conserving surgery (BCS) followed by radiotherapy (RT) is an
established treatment for women with T1-2N0 breast cancers. Since subgroups of patients …

Purpose: The majority of patients with early-stage breast cancer are treated with breast-
conserving therapy (BCT). Several clinical risk factors are associated with local recurrence …

We present a computational method, TuMult, for reconstructing the sequence of copy
number changes driving carcinogenesis, based on the analysis of several tumor samples …