Neuroinflammation is a complex biological process that plays a significant role in various
brain disorders. Microglia and astrocytes are the key cell types involved in inflammatory …

Opioid use disorder (OUD) is a major current cause of morbidity and mortality. Long-term
exposure to short-acting opioids (MOP-r agonists such as heroin or fentanyl) results in …

Traditional methods for site-specific drug delivery in the brain are slow, invasive, and difficult
to interface with recordings of neural activity. Here, we demonstrate the feasibility and …

A dysregulated circadian rhythm is significantly associated with cancer risk, as is aging. Both
aging and circadian dysregulation show suppressed pineal melatonin, which is indicated in …

Neuroinflammation plays an important role in the pathogenesis of neurological disorders,
and despite intensive research, treatment of neuroinflammation remains limited …

Over 50 million Americans endure chronic pain where many do not receive adequate
treatment and self-medicate to manage their pain by taking substances like opioids and …

Background Morphine is an opiate commonly used in the treatment of moderate to severe
pain. However, prolonged administration can lead to physical dependence and strong …

Abstract The Center for Disease Control and Prevention estimates that 75% of reported
cases of traumatic brain injury (TBI) are mild, where chronic pain and depression are 2 of the …

Experiments to study the biology of addiction have historically focused on the mechanisms
through which drugs of abuse drive changes in the functioning of neurons and neural …

Many neurological disorders are associated with neuroinflammation. Glial cells, including
astrocytes, are the primary brain cells involved in the mechanisms of neuroinflammation …