Throughout our lifespan, new sensory experiences and learning continually shape our
neuronal circuits to form new memories. Plasticity at the level of synapses has been …

Myelin, a lipid membrane that wraps axons, enabling fast neurotransmission and metabolic
support to axons, is conventionally thought of as a static structure that is set early in …

Ambient RNA contamination in single-cell and single-nuclei RNA sequencing (snRNA-seq)
is a significant problem, but its consequences are poorly understood. Here, we show that …

Abstract Transcription Factor 4 (TCF4) has been associated with autism, schizophrenia, and
other neuropsychiatric disorders. However, how pathological TCF4 mutations affect the …

Neural communication networks form the fundamental basis for brain function. These
communication networks are enabled by emitted ligands such as neurotransmitters, which …

The human transcription factor 4 gene (TCF4) encodes a helix–loop–helix transcription
factor widely expressed throughout the body and during neural development. Mutations in …

Despite enormous efforts employing various approaches, the molecular pathology in the
schizophrenia brain remains elusive. On the other hand, the knowledge of the association …

Autism spectrum disorders (ASDs) are a highly variable and complex set of neurological
disorders that alter neurodevelopment and cognitive function, which usually presents with …

Generation of oligodendrocytes in the adult brain enables both adaptive changes in neural
circuits and regeneration of myelin sheaths destroyed by injury, disease, and normal aging …

In the central and peripheral nervous systems, the myelin sheath promotes neuronal signal
transduction. The thickness of the myelin sheath changes during development and in …