The immune system and cancer have a complex relationship with the immune system
playing a dual role in tumor development. The effector cells of the immune system can …

The integrin αvβ3 plays an important role in angiogenesis. It is expressed on tumoral
endothelial cells as well as on some tumor cells. RGD peptides are well-known to bind …

Poor penetration of drugs into tumors is a major obstacle in tumor treatment. We describe a
strategy for peptide-mediated delivery of compounds deep into the tumor parenchyma that …

The various types of cells that comprise the tumor mass all carry molecular markers that are
not expressed or are expressed at much lower levels in normal cells. These differentially …

As the field of biotechnology has advanced, oral protein delivery has also made significant
progress. Oral delivery is the most common method of drug administration with high levels of …

Tumor necrosis factor (TNF) is a multifunctional cytokine that plays important roles in diverse
cellular events such as cell survival, proliferation, differentiation, and death. As a pro …

The success of cancer immunotherapy in solid tumors depends on a sufficient distribution of
effector T cells into malignant lesions. However, immune-cold tumors utilize many T-cell …

The use of nanoparticles in medicine (nanomedicine) has recently become an intensely
studied field. Nanoparticles carrying drugs and imaging agents have already reached the …

During the past decade, RGD-peptides have become a popular tool for the targeting of
drugs and imaging agents to αvβ3-integrin expressing tumour vasculature. RGD-peptides …

Peptides are attracting increasing attention as therapeutic agents, as the technologies for
peptide development and manufacture continue to mature. Concurrently, with booming …