The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …

Cyclic nucleotide phosphodiesterases (PDEs), which are ubiquitously distributed in
mammalian tissues, play a major role in cell signaling by hydrolyzing cAMP and cGMP. Due …

Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that have the unique function of
terminating cyclic nucleotide signaling by catalyzing the hydrolysis of cAMP and GMP. They …

When asked to draw up a list of textbook substituents, hardly anyone would consider to
associate such an “exotic entity” like trifluoromethoxy to the lastingly popular carboxy, acetyl …

cAMP is a second messenger that controls many key cellular functions. The only way to
inactivate cAMP is to degrade it through the action of cAMP phosphodiesterases (PDEs) …

Adaptations at the cellular and molecular levels in response to stress and antidepressant
treatment could represent a form of neural plasticity that contributes to the pathophysiology …

Spatiotemporal regulation of protein kinase A (PKA) activity involves the manipulation of
compartmentalized cAMP pools. Now we demonstrate that the muscle‐selective A‐kinase …

Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of
metallophosphohydrolases that specifically cleave the 3′, 5′-cyclic phosphate moiety of …

Lipopolysaccharide (LPS) stimulation of the innate immune response requires the activation
of signaling cascades that culminate in the synthesis and secretion of proinflammatory …

Phosphorylation of the β2 adrenoreceptor (β2AR) by cAMP-activated protein kinase A (PKA)
switches its predominant coupling from stimulatory guanine nucleotide regulatory protein …