The adaptive immune response is initiated by the interaction of T cell antigen receptors with
major histocompatibility complex molecule-peptide complexes in the nanometer scale gap …

The fluid mosaic membrane model proved to be a very useful hypothesis in explaining
many, but certainly not all, phenomena taking place in biological membranes. New …

Age is a non-modifiable risk factor for the inflammation that underlies age-associated
diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine …

The plasma membrane of cells is composed of lateral heterogeneities, patches and
microdomains. These membrane microdomains or lipid rafts are enriched in …

Obesity and type 2 diabetes are associated with chronic inflammation. Adiponectin is an
adipocyte-derived hormone with antidiabetic and antiinflammatory actions. Here, we …

Although IgE binding to mast cells is thought to be a passive presensitization step, we
demonstrate herein that monomeric IgE (mIgE) in the absence of antigen (Ag) stimulates …

[Frontiers in Bioscience 7, d1056-1183, May 1, 2002] 1056 T CELLS AND AGING,
JANUARY 2002 UPDATE Graham Pawelec1, Yvonne Barnett Page 1 [Frontiers in …

Background: Lipid rafts are currently an intensely investigated topic of cell biology. In
addition to a demonstrated role in signal transduction of the host cell, lipid rafts serve as …

Recent evidence implicates the actin cytoskeleton in the control of receptor signaling. This
may be of particular importance in the context of immune receptors, such as the B cell …

The C-type lectin dendritic cell (DC)–specific intercellular adhesion molecule grabbing non-
integrin (DC-SIGN; CD209) facilitates binding and internalization of several viruses …