The life of every organism is dependent on the fine-tuned mechanisms of protein synthesis
and breakdown. The degradation of most intracellular proteins is performed by the ubiquitin …

Cell-mediated immunity is driven by antigenic peptide presentation on major
histocompatibility complex (MHC) molecules. Specialized proteasome complexes called …

Previous studies indicate that microRNA-122 (miR-122) is down-regulated in several cancer
cells and regulates cell apoptosis, proliferation, metastasis, and tumor angiogenesis …

Chen Z, Tao Q, Qiao B, Zhang L. Cancer Manag Res. 2019; 11: 6043‒6059. The Editor and
Publisher of Cancer Management and Research wish to retract the published article …

The clinical outcome of oral squamous cell carcinoma (OSCC) has not improved in recent
years, mainly due to the limited effective targeted therapy that has been applied. Recently, a …

Increasing evidence supports that proteasome activator subunit (PSME) genes play an
indispensable role in multiple tumors. The diverse expression patterns, prognostic value …

At present, emerging evidence shows that non-coding RNAs (ncRNAs) play crucial roles for
development of multiple tumors. Amongst these ncRNAs, long non-coding RNAs (lncRNAs) …

PA28α/β activated immunoproteasome frequently participates in MHC class I antigen
processing, however, whether it is involved in breast tumor progression remains largely …

Super elongation complex (SEC) controls gene transcription by releasing Pol II from
pausing. Previous studies have shown that dysfunction of SEC was associated with multiple …

The proteasome is involved in the regulation of all cellular pathways and consequently plays
a central role in the control of cellular homeostasis. Together with its regulators, it is at the …