Routine health care and research have been profoundly influenced by digital-health
technologies. These technologies range from primary data collection in electronic health …

A randomized controlled trial is a prospective, comparative, quantitative study/experiment
performed under controlled conditions with random allocation of interventions to comparison …

Background Two glucagon-like peptide-1 (GLP-1) receptor agonists reduced renal
outcomes in people with type 2 diabetes at risk for cardiovascular disease. We assessed the …

The movement towards open science is a consequence of seemingly pervasive failures to
replicate previous research. This transition comes with great benefits but also significant …

Escrito por especialistas e atualizado conforme as abordagens clínicas mais recentes, o
livro Epidemiologia Clínica, de Grant S. Fletcher, aborda os princípios da medicina baseada …

Importance Previous trials have suggested that vasopressin and methylprednisolone
administered during in-hospital cardiac arrest might improve outcomes. Objective To …

Abstract Background The CONSORT (Consolidated Standards of Reporting Trials)
Statement was developed to help biomedical researchers report randomised controlled …

Openness and sharing of information are fundamental to the progress of science and to the
effective functioning of the research enterprise. The advent of scientific journals in the 17th …

Currently, there is a growing interest in ensuring the transparency and reproducibility of the
published scientific literature. According to a previous evaluation of 441 biomedical journals …

Background Sharing of participant-level clinical trial data has potential benefits, but
concerns about potential harms to research participants have led some pharmaceutical …