Zinc: dietary intake and impact of supplementation on immune function in elderly

E Mocchegiani, J Romeo, M Malavolta, L Costarelli… - Age, 2013 - Springer
The diet in the elderly does not provide a sufficient level of nutrients needed to maintain an
adequate healthy status leading to micronutrient deficiencies and impaired immune …

Low zinc status: a new risk factor for pneumonia in the elderly?

JB Barnett, DH Hamer, SN Meydani - Nutrition reviews, 2010 - academic.oup.com
Low zinc status may be a risk factor for pneumonia in the elderly. This special article reviews
the magnitude of the problem of pneumonia (its prevalence, morbidity, and mortality) in the …

Immunity and ageing in man

G Pawelec - Experimental gerontology, 2006 - Elsevier
Immunosenescence resulting in decreased ability to control infectious disease contributes to
morbidity and mortality not only in the very elderly, but in all likelihood already from middle …

Role of the immune system in aging and longevity

P Alonso-Fernández, M De la Fuente - Current aging science, 2011 - ingentaconnect.com
The aging process is a universal, intrinsic, progressive accumulation of deleterious changes
in cells and tissues that increases morbidity and leads to death. The heterogeneity of the …

Rebalancing the unbalanced aged immune system–A special focus on zinc

BR Baarz, L Rink - Ageing research reviews, 2022 - Elsevier
Nowadays, aging is understood as a dynamic and multifaceted dysregulation process that
spares almost no human organ or cell. The immune system being among the most affected …

Morphological substrates of cognitive decline in nonagenarians and centenarians: a new paradigm?

A Imhof, E Kövari, A von Gunten, G Gold… - Journal of the …, 2007 - Elsevier
Brain aging is characterized by the formation of neurofibrillary tangles (NFT) and senile
plaques (SP) in both cognitively intact individuals and patients with Alzheimer's disease …

Micronutrient–gene interactions related to inflammatory/immune response and antioxidant activity in ageing and inflammation. A systematic review

E Mocchegiani, L Costarelli, R Giacconi… - Mechanisms of ageing …, 2014 - Elsevier
Recent longitudinal studies in dietary daily intake in human centenarians have shown that a
satisfactory content of some micronutrients within the cells maintain several immune …

Inflammation, genes and zinc in Alzheimer's disease

S Vasto, G Candore, F Listì, CR Balistreri… - Brain Research …, 2008 - Elsevier
Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disease
which in Western society mainly accounts for clinical dementia. AD has been linked to …

Micronutrient (Zn, Cu, Fe)–gene interactions in ageing and inflammatory age-related diseases: implications for treatments

E Mocchegiani, L Costarelli, R Giacconi… - Ageing research …, 2012 - Elsevier
In ageing, alterations in inflammatory/immune response and antioxidant capacity lead to
increased susceptibility to diseases and loss of mobility and agility. Various essential …

Zinc-binding proteins (metallothionein and α-2 macroglobulin) and immunosenescence

E Mocchegiani, L Costarelli, R Giacconi… - Experimental …, 2006 - Elsevier
Zinc is a relevant trace element for the efficiency of the entire immune system. The binding of
zinc with some proteins, such as metallothioneins (MT) and α-2 macroglobulin (α-2M) is …