Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches

J Beermann, MT Piccoli, J Viereck… - Physiological …, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …

Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives

W Poller, S Dimmeler, S Heymans, T Zeller… - European heart …, 2018 - academic.oup.com
Recent research has demonstrated that the non-coding genome plays a key role in genetic
programming and gene regulation during development as well as in health and …

Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish

FO Kok, M Shin, CW Ni, A Gupta, AS Grosse… - Developmental cell, 2015 - cell.com
The widespread availability of programmable site-specific nucleases now enables targeted
gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate …

Noncoding RNA s in disease

E Lekka, J Hall - FEBS letters, 2018 - Wiley Online Library
Noncoding RNA s are emerging as potent and multifunctional regulators in all biological
processes. In parallel, a rapidly growing number of studies has unravelled associations …

MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles

E Van Rooij, EN Olson - Nature reviews Drug discovery, 2012 - nature.com
In recent years, prominent roles for microRNAs (miRNAs) have been uncovered in several
cardiovascular disorders. The ability to therapeutically manipulate miRNA expression and …

Long noncoding RNAs and microRNAs in cardiovascular pathophysiology

T Thum, G Condorelli - Circulation research, 2015 - Am Heart Assoc
RNAs not encoding proteins have gained prominence over the last couple of decades as
fundamental regulators of cellular function. Not surprisingly, their dysregulation is …

PAK signalling during the development and progression of cancer

M Radu, G Semenova, R Kosoff, J Chernoff - Nature reviews Cancer, 2014 - nature.com
Abstract p21-activated kinases (PAKs) are positioned at the nexus of several oncogenic
signalling pathways. Overexpression or mutational activation of PAK isoforms frequently …

MicroRNAs in myocardial infarction

RA Boon, S Dimmeler - Nature Reviews Cardiology, 2015 - nature.com
MicroRNAs (miRNAs) are small noncoding RNAs that block translation or induce
degradation of mRNA and thereby control patterns of gene expression. Acute myocardial …

microRNAs in cardiovascular diseases: current knowledge and the road ahead

G Condorelli, MVG Latronico, E Cavarretta - Journal of the American …, 2014 - jacc.org
Over the last few years, the field of microribonucleic acid (miRNA) in cardiovascular biology
and disease has expanded at an incredible pace. miRNAs are themselves part of a larger …

Animal models of heart failure: a scientific statement from the American Heart Association

SR Houser, KB Margulies, AM Murphy… - Circulation …, 2012 - Am Heart Assoc
Heart failure (HF) is a leading cause of morbidity and mortality in the United States. Despite
a number of important therapeutic advances for the treatment of symptomatic HF, 1 the …