Anhedonia is a core symptom of major depressive disorder (MDD), the neurobiological
mechanisms of which remain poorly understood. Despite decades of speculation regarding …

What roles do mesolimbic and neostriatal dopamine systems play in reward? Do they
mediate the hedonic impact of rewarding stimuli? Do they mediate hedonic reward learning …

Introduction Debate continues over the precise causal contribution made by mesolimbic
dopamine systems to reward. There are three competing explanatory categories:'liking' …

What are the neural substrates of food reward? Are reward and pleasure identical? Can
taste pleasure be assessed in animals? Is reward necessarily conscious? These questions …

The hedonic impact of taste is reflected in affective facial reactions made by human infants,
other primates, and even rats. Originally studied in human infants, affective reactions to taste …

Here we attempted to clarify the role of dopamine signaling in reward seeking. In Experiment
1, we assessed the effects of the dopamine D1/D2 receptor antagonist flupenthixol (0.5 …

The gustatory system serves as a critical line of defense against ingesting harmful
substances. Technological advances have fostered the characterization of peripheral …

Most theories describe motivation using basic terminology (drive,'wanting', goal, pleasure,
etc.) that fails to inform well about the psychological mechanisms controlling its expression …

Background: Because of the amphetamines' abuse potential and capability of exacerbating
or inducing mood and psychotic disturbances, investigations of the behavioral effects of …

Abstract Glucagon-like peptide-1 (GLP-1) is an incretin hormone that is essential for the
regulation of food intake and approved for the treatment of type 2 diabetes mellitus and …