Ferroptosis and its emerging roles in cardiovascular diseases

N Li, W Jiang, W Wang, R Xiong, X Wu… - Pharmacological Research, 2021 - Elsevier
Ferroptosis is a new form of regulated cell death (RCD) driven by iron-dependent lipid
peroxidation, which is morphologically and mechanistically distinct from other forms of RCD …

[HTML][HTML] Mechanistic concepts of iron-sulfur protein biogenesis in Biology

JJ Braymer, SA Freibert, M Rakwalska-Bange… - Biochimica et Biophysica …, 2021 - Elsevier
Abstract Iron-sulfur (Fe/S) proteins are present in virtually all living organisms and are
involved in numerous cellular processes such as respiration, photosynthesis, metabolic …

Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway

GH Chen, CC Song, K Pantopoulos, XL Wei… - Free Radical Biology …, 2022 - Elsevier
Ferroptosis is a regulated form of cell death induced by iron (Fe)-dependent lipid
peroxidation. At present, the underlying molecular mechanisms remain elusive. Herein, we …

Iron and cancer: 2020 vision

SV Torti, FM Torti - Cancer research, 2020 - AACR
New and provocative insights into the relationships between iron and cancer have been
uncovered in recent years. These include delineation of connections that link cellular iron to …

Iron homeostasis and organismal aging

RS Zeidan, SM Han, C Leeuwenburgh, R Xiao - Ageing research reviews, 2021 - Elsevier
Iron is indispensable for normal body functions across species because of its critical roles in
red blood cell function and many essential proteins and enzymes required for numerous …

miR‐29a‐3p in Exosomes from Heme Oxygenase‐1 Modified Bone Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver Ischemia‐Reperfusion Injury in Rats …

X Li, L Wu, X Tian, W Zheng, M Yuan… - Oxidative Medicine …, 2022 - Wiley Online Library
Hepatic ischemia‐reperfusion injury (IRI) is an inevitable result of liver surgery. Steatotic
livers are extremely sensitive to IRI and have worse tolerance. Ferroptosis is considered to …

Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus

X Gao, Y Song, J Wu, S Lu, X Min, L Liu… - The Journal of …, 2022 - Am Soc Clin Investig
The trace element iron affects immune responses and vaccination, but knowledge of its role
in autoimmune diseases is limited. Expansion of pathogenic T cells, especially T follicular …

Nutritional aspects of iron in health and disease

E Charlebois, K Pantopoulos - Nutrients, 2023 - mdpi.com
Dietary iron assimilation is critical for health and essential to prevent iron-deficient states
and related comorbidities, such as anemia. The bioavailability of iron is generally low, while …

The calcium–iron connection in ferroptosis-mediated neuronal death

S Gleitze, A Paula-Lima, MT Núñez… - Free Radical Biology and …, 2021 - Elsevier
Iron, through its participation in oxidation/reduction processes, is essential for the
physiological function of biological systems. In the brain, iron is involved in the development …

[HTML][HTML] Emerging mechanisms and targeted therapy of ferroptosis in neurological diseases and neuro-oncology

Y Wang, B Tang, J Zhu, J Yu, J Hui… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Ferroptosis is a novel type of cell death characterized by iron-dependent lipid peroxidation
that involves a variety of biological processes, such as iron metabolism, lipid metabolism …