Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview
Since human embryonic stem cells were first differentiated to beating cardiomyocytes a
decade ago, interest in their potential applications has increased exponentially. This has …
decade ago, interest in their potential applications has increased exponentially. This has …
Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions
The protocol described here efficiently directs human pluripotent stem cells (hPSCs) to
functional cardiomyocytes in a completely defined, growth factor–and serum-free system by …
functional cardiomyocytes in a completely defined, growth factor–and serum-free system by …
A simple bioreactor-based method to generate kidney organoids from pluripotent stem cells
Kidney organoids made from pluripotent stem cells have the potential to revolutionize how
kidney development, disease, and injury are studied. Current protocols are technically …
kidney development, disease, and injury are studied. Current protocols are technically …
Cellular and engineered organoids for cardiovascular models
An ensemble of in vitro cardiac tissue models has been developed over the past several
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
Development of a valve-based cell printer for the formation of human embryonic stem cell spheroid aggregates
A Faulkner-Jones, S Greenhough, JA King… - …, 2013 - iopscience.iop.org
In recent years, the use of a simple inkjet technology for cell printing has triggered
tremendous interest and established the field of biofabrication. A key challenge has been …
tremendous interest and established the field of biofabrication. A key challenge has been …
Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells
The creation of human induced pluripotent stem cells (hiPSCs) has provided an
unprecedented opportunity to study tissue morphogenesis and organ development through' …
unprecedented opportunity to study tissue morphogenesis and organ development through' …
Engineered microsystems for spheroid and organoid studies
Abstract 3D in vitro model systems such as spheroids and organoids provide an opportunity
to extend the physiological understanding using recapitulated tissues that mimic …
to extend the physiological understanding using recapitulated tissues that mimic …
Human pluripotent stem cells: an emerging model in developmental biology
Z Zhu, D Huangfu - Development, 2013 - journals.biologists.com
Developmental biology has long benefited from studies of classic model organisms.
Recently, human pluripotent stem cells (hPSCs), including human embryonic stem cells and …
Recently, human pluripotent stem cells (hPSCs), including human embryonic stem cells and …
In vitro cardiac tissue models: current status and future prospects
Cardiovascular disease is the leading cause of death worldwide. Achieving the next phase
of potential treatment strategies and better prognostic tools will require a concerted effort …
of potential treatment strategies and better prognostic tools will require a concerted effort …