Recent epidemiological studies have shown that, in addition to disease-specific effects,
vaccines against infectious diseases have nonspecific effects on the ability of the immune …

Coinfections involving viruses are being recognized to influence the disease pattern that
occurs relative to that with single infection. Classically, we usually think of a clinical …

The selenoenzyme glutathione peroxidase 4 (Gpx4) is a major scavenger of phospholipid
hydroperoxides. Although Gpx4 represents a key component of the reactive oxygen species …

In metazoans, specific tasks are relegated to dedicated organs that are established early in
development, occupy discrete locations and typically remain fixed in size. The adult immune …

The extent to which tissue-specific viral infections generate memory T cells specifically
adapted to and maintained within the target infection site is unknown. Here, we show that …

Abstract Naive CD4+ and CD8+ T cells undergo unique developmental programs after
activation, resulting in the generation of effector and long-lived memory T cells. Recent …

Evidence has accumulated that cytokines have a fundamental role in the differentiation of
memory T cells. Here, we follow the CD8+ T cell from initial activation to memory-cell …

The adaptive immune response meets the needs of the organism to generate effector cells
capable of controlling pathogens but also leads to production of memory cells, which …

CD8 T cells respond to viral infections but also participate in defense against bacterial and
protozoal infections. In the last few years, as new methods to accurately quantify and …

The most popular hypothesis circulating within and beyond the scientific community is that
viral infections enhance or elicit autoimmune disorders such as type 1 diabetes. Indeed …