Cellular senescence is characterized as a stable proliferation arrest that can be triggered by
multiple stresses. Most knowledge about senescent cells is obtained from studies in primary …

Major obstacles in brain cancer treatment include the blood-tumor barrier (BTB), which limits
the access of most therapeutic agents, and quiescent tumor cells, which resist conventional …

Circular RNAs (circRNAs), a novel class of widespread and diverse endogenous RNAs, can
regulate gene expression in mammals. CircRNAs have recently been identified as …

Hormone-sensitive prostate cancer typically progresses to castration resistant prostate
cancer (CRPC) after the androgen deprivation therapy. We investigated the impact of …

Chemoresistance to platinums, such as cisplatin, is of critical concern in the treatment of
ovarian cancer. Recent evidence has linked epithelial–mesenchymal transition (EMT) as a …

Systemic lupus erythematosus (SLE) is an autoimmune disease. It is characterized by the
production of various pathogenic autoantibodies and is suggested to be triggered by …

Therapeutic antibodies sometimes elicit anti-drug antibodies (ADAs) that can affect efficacy
and safety. Engineered antibodies that contain artificial amino acid sequences are …

Small-cell lung cancer (SCLC) is a recalcitrant malignancy that urgently needs new
therapies. Four master transcription factors (ASCL1, NEUROD1, POU2F3, and YAP1) have …

UXT is widely expressed in human and mouse tissues and aberrantly expressed in various
tumor tissues. UXT may play a pro-cancer or tumor suppressor role in different tumor types …

Introduction Gene expression data derived from clinical cancer specimens provide an
opportunity to characterize cancer-specific transcriptional programs. Here, we present an …