The Cancer SENESCopedia: A delineation of cancer cell senescence
F Jochems, B Thijssen, G De Conti, R Jansen… - Cell reports, 2021 - cell.com
Cellular senescence is characterized as a stable proliferation arrest that can be triggered by
multiple stresses. Most knowledge about senescent cells is obtained from studies in primary …
multiple stresses. Most knowledge about senescent cells is obtained from studies in primary …
Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity
Major obstacles in brain cancer treatment include the blood-tumor barrier (BTB), which limits
the access of most therapeutic agents, and quiescent tumor cells, which resist conventional …
the access of most therapeutic agents, and quiescent tumor cells, which resist conventional …
Emerging roles of circular RNA hsa_circ_0000064 in the proliferation and metastasis of lung cancer
YH Luo, XZ Zhu, KW Huang, Q Zhang, YX Fan… - Biomedicine & …, 2017 - Elsevier
Circular RNAs (circRNAs), a novel class of widespread and diverse endogenous RNAs, can
regulate gene expression in mammals. CircRNAs have recently been identified as …
regulate gene expression in mammals. CircRNAs have recently been identified as …
MiR-221 promotes the development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A
Hormone-sensitive prostate cancer typically progresses to castration resistant prostate
cancer (CRPC) after the androgen deprivation therapy. We investigated the impact of …
cancer (CRPC) after the androgen deprivation therapy. We investigated the impact of …
Epithelial–mesenchymal status renders differential responses to cisplatin in ovarian cancer
Chemoresistance to platinums, such as cisplatin, is of critical concern in the treatment of
ovarian cancer. Recent evidence has linked epithelial–mesenchymal transition (EMT) as a …
ovarian cancer. Recent evidence has linked epithelial–mesenchymal transition (EMT) as a …
Interferon α Enhances B Cell Activation Associated With FOXM1 Induction: Potential Novel Therapeutic Strategy for Targeting the Plasmablasts of Systemic Lupus …
K Akita, K Yasaka, T Shirai, T Ishii, H Harigae… - Frontiers in …, 2021 - frontiersin.org
Systemic lupus erythematosus (SLE) is an autoimmune disease. It is characterized by the
production of various pathogenic autoantibodies and is suggested to be triggered by …
production of various pathogenic autoantibodies and is suggested to be triggered by …
Rapid in vitro assessment of the immunogenicity potential of engineered antibody therapeutics through detection of CD4+ T cell interleukin-2 secretion
Y Arata, S Motoyama, M Yano, T Ikuno, S Ito… - MAbs, 2023 - Taylor & Francis
Therapeutic antibodies sometimes elicit anti-drug antibodies (ADAs) that can affect efficacy
and safety. Engineered antibodies that contain artificial amino acid sequences are …
and safety. Engineered antibodies that contain artificial amino acid sequences are …
BET inhibitors target the SCLC-N subtype of small-cell lung cancer by blocking NEUROD1 transactivation
Small-cell lung cancer (SCLC) is a recalcitrant malignancy that urgently needs new
therapies. Four master transcription factors (ASCL1, NEUROD1, POU2F3, and YAP1) have …
therapies. Four master transcription factors (ASCL1, NEUROD1, POU2F3, and YAP1) have …
The role of UXT in tumors and prospects for its application in hepatocellular carcinoma
Z Wang, S Mo, P Han, L Liu, Z Liu, X Fu, Y Tian - Future Oncology, 2022 - Taylor & Francis
UXT is widely expressed in human and mouse tissues and aberrantly expressed in various
tumor tissues. UXT may play a pro-cancer or tumor suppressor role in different tumor types …
tumor tissues. UXT may play a pro-cancer or tumor suppressor role in different tumor types …
The gene expression landscape of breast cancer is shaped by tumor protein p53 status and epithelial-mesenchymal transition
Introduction Gene expression data derived from clinical cancer specimens provide an
opportunity to characterize cancer-specific transcriptional programs. Here, we present an …
opportunity to characterize cancer-specific transcriptional programs. Here, we present an …