BACKGROUND Human reproductive issues affecting fetal and maternal health are caused
by numerous exogenous and endogenous factors, of which the latter undoubtedly include …

Beckwith-Wiedemann syndrome (BWS) is a clinically and genetically heterogeneous
overgrowth disease. BWS is caused by (epi) genetic defects at the 11p15 chromosomal …

In mammals, imprinted genes are regulated by differentially methylated regions (DMRs) that
are inherited from germ cells, leading to monoallelic expression in accordance with parent …

Methylation tests have been used for decades in regular DNA diagnostics focusing primarily
on Imprinting disorders or specific loci annotated to specific disease associated gene …

DNA methylation in the human genome is largely programmed and shaped by transcription
factor binding and interaction between DNA methyltransferases and histone marks during …

Background Imprinting disorders are rare diseases resulting from altered expression of
imprinted genes, which exhibit parent-of-origin-specific expression patterns regulated …

Genomic imprinting is a term used for an intergenerational epigenetic inheritance and
involves a subset of genes expressed in a parent-of-origin-dependent way. Imprinted genes …

Abstract Background Imprinting disorders (ImpDis) comprise diseases which are caused by
aberrant regulation of monoallelically and parent-of-origin-dependent expressed genes. A …

Imprinting disorders are a group of congenital diseases caused by dysregulation of genomic
imprinting, affecting prenatal and postnatal growth, neurocognitive development …

DNA methylation controls several cellular processes, from early development to old age,
including biological responses to endogenous or exogenous stimuli contributing to disease …