Highlights•Phagocytes play both protective and detrimental roles in containing bloodstream
S. aureus.•S. aureus hijacks the host coagulation system and uses it to bind host …

Staphylococcus aureus is one of the most important human pathogens worldwide. Its high
antibiotic resistance profile reinforces the need for new interventions like vaccines in …

Invasive Staphylococcus aureus infections are a leading cause of morbidity and mortality in
both hospital and community settings, especially with the widespread emergence of virulent …

As a major arm of the cellular immune response, CD4+ T cells are important in the control
and clearance of infections. Primarily described as helpers, CD4+ T cells play an integral …

Staphylococcus aureus is both a commensal organism and also an important opportunistic
human pathogen, causing a variety of community and hospital-associated pathologies, such …

Staphylococcus aureus (S. aureus) causes the vast majority of skin and soft tissue infections
(SSTIs) in humans. S. aureus has become increasingly resistant to antibiotics and there is …

While immunoglobulin (Ig) E is a prominent biomarker for early-onset, its levels are often
elevated in non-allergic late-onset asthma. However, the pattern of IgE expression in the …

The human body frequently encounters harmful bacterial pathogens and employs immune
defense mechanisms designed to counteract such pathogenic assault. In the adaptive …

Nucleic acid vaccines represent an attractive approach to vaccination, combining the
positive attributes of both viral vectors and live-attenuated vaccines, without the inherent …

Staphylococcal superantigens (SAgs) constitute a family of potent exotoxins secreted by
Staphylococcus aureus and other select staphylococcal species. SAgs function to cross-link …