Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials
EE Patton, LI Zon, DM Langenau - Nature Reviews Drug Discovery, 2021 - nature.com
Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …
[HTML][HTML] Image-based profiling for drug discovery: due for a machine-learning upgrade?
SN Chandrasekaran, H Ceulemans, JD Boyd… - Nature Reviews Drug …, 2021 - nature.com
Image-based profiling is a maturing strategy by which the rich information present in
biological images is reduced to a multidimensional profile, a collection of extracted image …
biological images is reduced to a multidimensional profile, a collection of extracted image …
Use of zebrafish in drug discovery toxicology
Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …
health and money. The drug discovery industry attempts to minimize those events with …
Resting-state connectivity biomarkers define neurophysiological subtypes of depression
Biomarkers have transformed modern medicine but remain largely elusive in psychiatry,
partly because there is a weak correspondence between diagnostic labels and their …
partly because there is a weak correspondence between diagnostic labels and their …
Quantitative investigation of the mechanisms of microplastics and nanoplastics toward zebrafish larvae locomotor activity
This study investigated the direct and indirect toxic effects of microplastics and nanoplastics
toward zebrafish (Danio rerio) larvae locomotor activity. Results showed that microplastics …
toward zebrafish (Danio rerio) larvae locomotor activity. Results showed that microplastics …
[HTML][HTML] Zebrafish larvae as a behavioral model in neuropharmacology
Zebrafish larvae show a clear and distinct pattern of swimming in response to light and dark
conditions, following the development of a swim bladder at 4 days post fertilization. This …
conditions, following the development of a swim bladder at 4 days post fertilization. This …
Zebrafish as tools for drug discovery
CA MacRae, RT Peterson - Nature reviews Drug discovery, 2015 - nature.com
The zebrafish has become a prominent vertebrate model for disease and has already
contributed to several examples of successful phenotype-based drug discovery. For the …
contributed to several examples of successful phenotype-based drug discovery. For the …
Zebrafish in toxicology and environmental health
K Bambino, J Chu - Current topics in developmental biology, 2017 - Elsevier
As manufacturing processes and development of new synthetic compounds increase to
keep pace with the expanding global demand, environmental health, and the effects of …
keep pace with the expanding global demand, environmental health, and the effects of …
[HTML][HTML] Zebrafish larvae behavior models as a tool for drug screenings and pre-clinical trials: a review
To discover new molecules or review the biological activity and toxicity of therapeutic
substances, drug development, and research relies on robust biological systems to obtain …
substances, drug development, and research relies on robust biological systems to obtain …
Zebrafish: development of a vertebrate model organism
JR Meyers - Current Protocols Essential Laboratory …, 2018 - Wiley Online Library
Zebrafish (Danio rerio) are a small‐bodied tropical, freshwater fish species originally from
South Asia. The ease of care, year‐round prolific breeding, and transparent, external …
South Asia. The ease of care, year‐round prolific breeding, and transparent, external …