During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …

Abstract p63, p73 and p53 compose a family of transcription factors involved in cell
response to stress and development. p53 is the most frequently mutated gene in cancer …

The p53 tumor suppressor gene is commonly altered in human tumors, predominantly
through missense mutations that result in accumulation of mutant p53 protein. These …

p73 and p63 are two homologs of the tumor suppressive transcription factor p53. Given the
high degree of structural similarity shared by the p53 family members, p73 and p63 can bind …

As p53 and its homologue p73 have significant sequence and functional similarities, p73
might also be expected to act as a tumour suppressor. However, p73 is activated after DNA …

The tumor suppressor p53 is critically important in the cellular damage response and is the
founding member of a family of proteins. All three genes regulate cell cycle and apoptosis …

p73, an important developmental gene, shares a high sequence homology with p53 and
induces both G 1 cell cycle arrest and apoptosis. However, the molecular mechanisms …

The role of p53 as a tumour suppressor is generally attributed to its ability to stop the
proliferation of precancerous cells by inducing cell-cycle arrest or apoptosis. The relatives …

p73, a member of the p53 family of transcription factors, is upregulated in response to DNA
damage, inducing cell cycle arrest and apoptosis. Besides indications that this p73 response …

TP63, an important epithelial developmental gene, has significant homology to p53. Unlike
p53, the expression of p63 is regulated by two different promoters resulting in proteins with …