The bacterial pathogen Helicobacter pylori has co-evolved with humans and colonizes
approximately 50% of the human population, but only causes overt gastric disease in a …

Infections are estimated to contribute to 20% of all human tumours. These are mainly caused
by viruses, which explains why a direct bacterial contribution to cancer formation has been …

The epidermal growth factor receptor (EGFR) is the prototypical member of a family of
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …

Summary The Helicobacter pylori (Hp) type IV secretion system (T4SS) forms needle-like
pili, whose binding to the integrin-β 1 receptor results in injection of the CagA oncoprotein …

Many Gram-negative pathogens harbor type IV secretion systems (T4SS) that translocate
bacterial virulence factors into host cells to hijack cellular processes. The pathology of the …

The discovery of Helicobacter pylori overturned the conventional dogma that the stomach
was a sterile organ and that pH values< 4 were capable of sterilizing the stomach. H. pylori …

Infections with the human pathogen Helicobacter pylori (H. pylori) can lead to severe gastric
diseases ranging from chronic gastritis and ulceration to neoplastic changes in the stomach …

Helicobacter pylori (H. pylori) infection is one of the most common infections in human
beings worldwide. H. pylori express lipopolysaccharides and flagellin that do not activate …

A section of gastric cancers presents nuclear β-catenin accumulation correlated with H.
pylori infection. H. pylori stimulate Wnt/β-catenin pathway by activating oncogenic c-Met and …

Helicobacter pylori colonizes the gastric mucosa in the human stomach and represents a
major risk factor for peptic ulcer disease and gastric cancer. Here, we summarize our current …