Liver regeneration is a complex process involving the crosstalk of multiple cell types,
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …

Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Ductular reaction (DR) is characterized by the proliferation of reactive bile ducts induced by
liver injuries. DR is pathologically recognized as bile duct hyperplasia and is commonly …

YAP and TAZ are ubiquitously expressed homologous proteins originally identified as
penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining …

Tissue regeneration is a process by which the remaining cells of an injured organ regrow to
offset the missed cells. This field is relatively a new discipline that has been a focus of …

How the behavior of cells in living tissues is orchestrated according to tissue needs, size,
and developmental stage is still poorly understood. Advances in these directions are …

The Notch signaling pathway plays major roles in organ development across animal
species. In the mammalian liver, Notch has been found critical in development, regeneration …

The liver is a unique parenchymal organ with a regenerative capacity allowing it to restore
up to 70% of its volume. Although knowledge of this phenomenon dates back to Greek …

The liver, in combination with a functional biliary system, is responsible for maintaining a
great number of vital body functions. However, acute and chronic liver diseases may lead to …

Primary liver cancer comprises a diverse group of liver tumors. The heterogeneity of these
tumors is seen as one of the obstacles to finding an effective therapy. The Hippo pathway …