The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-
1α (PGC-1α) regulates metabolic genes in skeletal muscle and contributes to the response …

Transcription activator-like effector nucleases (TALENs) are a new class of engineered
nucleases that are easier to design to cleave at desired sites in a genome than previous …

Since the generation of the first induced pluripotent stem (iPS) cells, the stem cell field has
grown at an unparalleled pace. Today, these cells have become the major tools in the …

Whole-exome sequencing of autism spectrum disorder (ASD) probands and unaffected
family members has identified many genes harboring de novo variants suspected to play a …

Human induced pluripotent stem (iPS) cell technologies coupled with genetic engineering
now facilitate the study of the molecular underpinnings of disease in relevant human cell …

Neurogenins are proneural transcription factors required to specify neuronal identity. Their
overexpression in human pluripotent stem cells rapidly produces cortical-like neurons with …

In addition to their promise in regenerative medicine, pluripotent stem cells have proved to
be faithful models of many human diseases. In particular, patient-specific stem cell-derived …

Parkinson's disease (PD) is a complex and highly variable neurodegenerative disease.
Familial PD is caused by mutations in several genes with diverse and mostly unknown …

Genome editing is used to make targeted modifications to the genome of eukaryotic cells.
There are many potential applications of genome editing in human pluripotent stem cells …

In pluripotent cells, a delicate activation-repression balance maintains pro-differentiation
genes ready for rapid activation. The identity of transcription factors (TFs) that specifically …