Role of Porphyromonas gingivalis in oral and orodigestive squamous cell carcinoma

RJ Lamont, ZR Fitzsimonds, H Wang… - Periodontology …, 2022 - Wiley Online Library
Oral and esophageal squamous cell carcinomas harbor a diverse microbiome that differs
compositionally from precancerous and healthy tissues. Though causality is yet to be …

[HTML][HTML] Porphyromonas gingivalis and Its Systemic Impact: Current Status

F Mei, M Xie, X Huang, Y Long, X Lu, X Wang, L Chen - Pathogens, 2020 - mdpi.com
The relationship between periodontitis and systemic diseases, notably including
atherosclerosis and diabetes, has been studied for several years. Porphyromonas …

[HTML][HTML] The role of reactive oxygen species and autophagy in periodontitis and their potential linkage

C Liu, L Mo, Y Niu, X Li, X Zhou, X Xu - Frontiers in physiology, 2017 - frontiersin.org
Periodontitis is a chronic inflammatory disease that causes damage to periodontal tissues,
which include the gingiva, periodontal ligament, and alveolar bone. The major cause of …

[HTML][HTML] Mucosal immunity and the FOXO1 transcription factors

DT Graves, TN Milovanova - Frontiers in immunology, 2019 - frontiersin.org
FOXO1 transcription factors affect a number of cell types that are important in the host
response. Cell types whose functions are modulated by FOXO1 include keratinocytes in the …

[HTML][HTML] Pathways that regulate ROS scavenging enzymes, and their role in defense against tissue destruction in periodontitis

H Kanzaki, S Wada, T Narimiya, Y Yamaguchi… - Frontiers in …, 2017 - frontiersin.org
Periodontitis, an inflammatory disease that affects the tissues surrounding the teeth, is a
common disease worldwide. It is caused by a dysregulation of the host inflammatory …

Immunological Pathways Triggered by Porphyromonas gingivalis and Fusobacterium nucleatum: Therapeutic Possibilities?

KQ De Andrade, CLC Almeida-da-Silva… - Mediators of …, 2019 - Wiley Online Library
Porphyromonas gingivalis (P. gingivalis) and Fusobacterium nucleatum (F. nucleatum) are
Gram‐negative anaerobic bacteria possessing several virulence factors that make them …

Metabolic crosstalk regulates Porphyromonas gingivalis colonization and virulence during oral polymicrobial infection

M Kuboniwa, JR Houser, EL Hendrickson, Q Wang… - Nature …, 2017 - nature.com
Many human infections are polymicrobial in origin, and interactions among community
inhabitants shape colonization patterns and pathogenic potential. Periodontitis, which is the …

The function of dendritic cells in modulating the host response

L Song, G Dong, L Guo… - Molecular oral …, 2018 - Wiley Online Library
Dendritic cells (DC s) are antigen‐presenting cells that capture, process, and present
antigens to lymphocytes to initiate and regulate the adaptive immune response. DC s detect …

[HTML][HTML] Cathelicidin LL-37 in health and diseases of the oral cavity

J Tokajuk, P Deptuła, E Piktel, T Daniluk… - Biomedicines, 2022 - mdpi.com
The mechanisms for maintaining oral cavity homeostasis are subject to the constant
influence of many environmental factors, including various chemicals and microorganisms …

Targeting reactive oxygen species in stem cells for bone therapy

X Li, B Li, Y Shi, C Wang, L Ye - Drug Discovery Today, 2021 - Elsevier
Highlights•ROS critically regulate the fate and function of stem cells from non-hematopoietic
and hematopoietic lineage to control bone hemostasis.•Excessive ROS accumulation in …