FLASH: New intersection of physics, chemistry, biology, and cancer medicine
Ultrahigh dose rate, FLASH radiotherapy has emerged as one of the most promising
innovations over the past decade in the field of radiation oncology, with the potential to …
innovations over the past decade in the field of radiation oncology, with the potential to …
[HTML][HTML] Framework for quality assurance of ultrahigh dose rate clinical trials investigating FLASH effects and current technology gaps
Abstract FLASH radiation therapy (FLASH-RT), delivered with ultrahigh dose rate (UHDR),
may allow patients to be treated with less normal tissue toxicity for a given tumor dose …
may allow patients to be treated with less normal tissue toxicity for a given tumor dose …
[HTML][HTML] FLASH radiotherapy treatment planning and models for electron beams
M Rahman, A Trigilio, G Franciosini, R Moeckli… - Radiotherapy and …, 2022 - Elsevier
The FLASH effect designates normal tissue sparing at ultra-high dose rate (UHDR,> 40
Gy/s) compared to conventional dose rate (∼ 0.1 Gy/s) irradiation while maintaining tumour …
Gy/s) compared to conventional dose rate (∼ 0.1 Gy/s) irradiation while maintaining tumour …
Flash radiotherapy: Expectations, challenges, and current knowledge
A Borghini, L Labate, S Piccinini, CMV Panaino… - International Journal of …, 2024 - mdpi.com
Major strides have been made in the development of FLASH radiotherapy (FLASH RT) in
the last ten years, but there are still many obstacles to overcome for transfer to the clinic to …
the last ten years, but there are still many obstacles to overcome for transfer to the clinic to …
Dose and dose rate objectives in Bragg peak and shoot‐through beam orientation optimization for FLASH proton therapy
Purpose The combined use of Bragg peak (BP) and shoot‐through (ST) beams has
previously been shown to increase the normal tissue volume receiving FLASH dose rates …
previously been shown to increase the normal tissue volume receiving FLASH dose rates …
Pulse parameter optimizer: an efficient tool for achieving prescribed dose and dose rate with electron FLASH platforms
Purpose. Commercial electron FLASH platforms deliver ultra-high dose rate doses at
discrete combinations of pulse parameters including pulse width (PW), pulse repetition …
discrete combinations of pulse parameters including pulse width (PW), pulse repetition …
Feasibility study of multiple‐energy Bragg peak proton FLASH on a superconducting gantry with large momentum acceptance
Abstract Background While the Bragg peak proton beam (BP) is capable of superior target
conformity and organs‐at‐risk sparing than the transmission proton beam (TB), its efficacy in …
conformity and organs‐at‐risk sparing than the transmission proton beam (TB), its efficacy in …
Diamond detectors for dose and instantaneous dose‐rate measurements for ultra‐high dose‐rate scanned helium ion beams
T Tessonnier, G Verona‐Rinati, L Rank… - Medical …, 2024 - Wiley Online Library
Background The possible emergence of the FLASH effect—the sparing of normal tissue
while maintaining tumor control—after irradiations at dose‐rates exceeding several tens of …
while maintaining tumor control—after irradiations at dose‐rates exceeding several tens of …
[HTML][HTML] C. elegans: A potent model for high-throughput screening experiments investigating the FLASH effect
This study explores the effects of UHDR irradiation on Caenorhabditis elegans embryos.
UHDR proton and electron beams demonstrate a sparing effect, aligning with literature …
UHDR proton and electron beams demonstrate a sparing effect, aligning with literature …
Recording and reporting of ultra-high dose rate “FLASH” delivery for preclinical and clinical settings
Treatments at ultra-high dose rate (UHDR) have the potential to improve the therapeutic
index of radiation therapy (RT) by sparing normal tissues compared to conventional dose …
index of radiation therapy (RT) by sparing normal tissues compared to conventional dose …