Gap junctions (GJs) are the only known cellular structures that allow a direct transfer of
signaling molecules from cell-to-cell by forming hydrophilic channels that bridge the …

The eye lens is constantly subjected to oxidative stress from radiation and other sources.
The lens has several mechanisms to protect its components from oxidative stress and to …

Gap junctions were initially described morphologically, and identified as semi-crystalline
arrays of channels linking two cells. This suggested that they may represent an amenable …

Antinuclear autoantibodies (ANAs) displaying the nuclear dense fine speckled
immunofluorescence (DFS-IIF) pattern in HEp-2 substrates are commonly observed in …

Connexin43 (Cx43) is a membrane-spanning protein that forms channels that bridge the
gap between adjacent cells and this allows for the intercellular exchange of information …

The accumulation of reactive oxygen species (ROS, for example H 2 O 2) is linked to several
chronic pathologies, including cancer and cardiovascular and neurodegenerative diseases …

Autoantibodies against DFS70 (Dense Fine Speckles 70) are found in 30% of Japanese
atopic dermatitis patients, and less frequently in patients with other diseases. We have …

The risk and severity of ovarian carcinoma, the leading cause of gynecologic malignancy
death, are significantly elevated in postmenopausal women. Ovarian failure at menopause …

The avascular lens of the eye is covered anteriorly by an epithelium containing nucleated,
metabolically active cells. This epithelium contains the first lens cells to encounter noxious …

Vascular endothelial growth factor C (VEGF-C) plays a critical role in tumor
lymphangiogenesis and lymph node metastasis. We report here that VEGF-C expression is …