Development of the anterior segment of the eye requires reciprocal sequential interactions
between the arising tissues, facilitated by numerous genetic factors. Disruption of any of …

Visual impairment and blindness are common and seriously affect people's work and quality
of life in the world. Therefore, the effective therapies for eye diseases are of high priority …

Purpose To report the relative frequencies of childhood and early onset glaucoma subtypes
and their genetic findings in a large single cohort. Design Retrospective clinical and …

Background Haploinsufficiency of the transcription factor PAX6 is the main cause of
congenital aniridia, a genetic disorder characterized by iris and foveal hypoplasia. 11p13 …

Monogenic syndromic disorders frequently feature ocular manifestations, one of which is
glaucoma. In many cases, glaucoma in children may go undetected, especially in those that …

Anterior segment dysgenesis is a severe developmental eye disorder that leads to blindness
in children. The exact mechanisms underlying this condition remain elusive. Recently, an …

Aniridia is a panocular disease characterized by iris hypoplasia, accompanied by other
ocular manifestations, with a high clinical variability and overlapping with different …

Childhood glaucoma is a heterogeneous group of ocular disorders defined by an age of
onset from birth to 18 years. These vision‐threatening disorders require early diagnosis …

Primary congenital glaucoma is an important cause of visual impairment in children. It can
develop both pre-and postnatally. Angle surgery is the first line treatment modality. If the …

Schistosomiasis is a disease caused by trematode parasites of the genus Schistosoma that
affects approximately 200 million people worldwide. Schistosomiasis has been a persistent …