Abstract Context Prostate cancer (PCa) is a clinically heterogeneous disease with marked
variability in patient outcomes. Molecular characterization has revealed striking mutational …

Although prostate cancer is the most common malignancy to affect men in the Western
world, the molecular mechanisms underlying its development and progression remain …

Background: Whether the genomic rearrangement transmembrane protease, serine 2
(TMPRSS2): v-ets erythroblastosis virus E26 oncogene homolog (ERG) has prognostic …

Studies of ETS-mediated prostate oncogenesis have been hampered by a lack of suitable
experimental systems. Here we describe a new conditional mouse model that shows robust …

Abstract The Androgen Receptor (AR) is the key-driving transcription factor in prostate
cancer, tightly controlled by epigenetic regulation. To date, most epigenetic profiling has …

Enabled by high-throughput sequencing approaches, epithelial cancers across a range of
tissue types are seen to harbor gene fusions as integral to their landscape of somatic …

Chromosomal rearrangements resulting in the fusion of TMPRSS2, an androgen-regulated
gene, and the ETS family transcription factor ERG occur in over half of prostate cancers …

Prostate cancer is a clinically heterogeneous disease, with some men having indolent
disease that can safely be observed, while others have aggressive, lethal disease. Over the …

Friend leukemia virus-induced erythroleukemia-1 (Fli-1), an E26 transformation specific
(ETS) transcription factor, was isolated a quarter century ago through a retrovirus …

ERG gene encodes for an Ets family regulatory transcription factor and is involved in
recurrent chromosomal translocations found in a subset of acute myeloid leukemias …