Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an
essential component of tumour dissemination during progression and metastasis. This …

Mechanotransduction has been a topic of considerable interest since early studies
demonstrated a link between mechanical force and biological response. Until recently …

Tumor cell migration is essential for invasion and dissemination from primary solid tumors
and for the establishment of lethal secondary metastases at distant organs. In vivo and in …

We have shown previously that distinct Mena isoforms are expressed in invasive and
migratory tumor cells in vivo and that the invasion isoform (MenaINV) potentiates carcinoma …

While it has been established that a number of microenvironment components can affect the
likelihood of metastasis, the link between microenvironment and tumor cell phenotypes is …

Microfluidic devices can better control cellular microenvironments compared to conventional
cell migration assays. Over the past few years, microfluidics-based chemotaxis studies …

Microfluidics has emerged as a powerful laboratory toolbox for biologists, allowing
manipulation and analysis of processes at a cellular and sub-cellular level, through …

Chemokine-mediated directed tumor cell migration within a three dimensional (3D) matrix,
or chemoinvasion, is an important early step in cancer metastasis. Despite its clinical …

Microneedles are a relatively simple, minimally invasive and painless approach to deliver
drugs across the skin. However, there remain limitations with this approach because of the …

Background Cancer is a highly complex disease, which involves the cooperation of tumor
cells with multiple types of host cells and the extracellular matrix. Cancer studies that rely …