Chronic wounds: Current status, available strategies and emerging therapeutic solutions

K Las Heras, M Igartua, E Santos-Vizcaino… - Journal of controlled …, 2020 - Elsevier
In the past decades, adequate and well-planned management of chronic wounds has
reached an elevated importance to improve human's quality of life and extend life …

Perlecan, a multi-functional, cell-instructive, matrix-stabilizing proteoglycan with roles in tissue development has relevance to connective tissue repair and …

AJ Hayes, BL Farrugia, IJ Biose, GJ Bix… - Frontiers in Cell and …, 2022 - frontiersin.org
This review highlights the multifunctional properties of perlecan (HSPG2) and its potential
roles in repair biology. Perlecan is ubiquitous, occurring in vascular, cartilaginous, adipose …

New injectable chitosan-hyaluronic acid based hydrogels for hemostasis and wound healing

H Weng, W Jia, M Li, Z Chen - Carbohydrate polymers, 2022 - Elsevier
It is a challenge to develop hemostatic and wound dressings that are used for irregular
shape and deep wound. Herein, a series of novel N-succinyl chitosan-oxidized hyaluronic …

[HTML][HTML] The impact of TRPV1 on cancer pathogenesis and therapy: a systematic review

L Li, C Chen, C Chiang, T Xiao, Y Chen… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
The transient receptor potential cation channel subfamily V member 1 (TRPV1) is a
transmembrane protein that can be activated by various physical and chemical stimuli and is …

[HTML][HTML] Significance of sphingosine-1-phosphate in cardiovascular physiology and pathology

E Józefczuk, TJ Guzik, M Siedlinski - Pharmacological research, 2020 - Elsevier
Abstract Sphingosine-1-phosphate (S1P) is a signaling lipid, synthetized by sphingosine
kinases (SPHK1 and SPHK2), that affects cardiovascular function in various ways. S1P …

Metal ions: The unfading stars of bone regeneration—From bone metabolism regulation to biomaterial applications

Y Luo, H Liu, Y Zhang, Y Liu, S Liu, X Liu… - Biomaterials Science, 2023 - pubs.rsc.org
In recent years, bone regeneration has emerged as a remarkable field that offers promising
guidance for treating bone-related diseases, such as bone defects, bone infections, and …

Bacterial lipopolysaccharide-induced endothelial activation and dysfunction: a new predictive and therapeutic paradigm for sepsis

M Wang, J Feng, D Zhou, J Wang - European Journal of Medical Research, 2023 - Springer
Background Lipopolysaccharide, a highly potent endotoxin responsible for severe sepsis, is
the major constituent of the outer membrane of gram-negative bacteria. Endothelial cells …

[HTML][HTML] Wireless electrical stimulation at the nanoscale interface induces tumor vascular normalization

C Li, C Xiao, L Zhan, Z Zhang, J Xing, J Zhai, Z Zhou… - Bioactive Materials, 2022 - Elsevier
Pathological angiogenesis frequently occurs in tumor tissue, limiting the efficiency of
chemotherapeutic drug delivery and accelerating tumor progression. However, traditional …

Endothelial Transient Receptor Potential Channels and Vascular Remodeling: Extracellular Ca2 + Entry for Angiogenesis, Arteriogenesis and Vasculogenesis

S Negri, P Faris, R Berra-Romani, G Guerra… - Frontiers in …, 2020 - frontiersin.org
Vasculogenesis, angiogenesis and arteriogenesis represent three crucial mechanisms
involved in the formation and maintenance of the vascular network in embryonal and post …

Reactive Oxygen Species and Endothelial Ca2+ Signaling: Brothers in Arms or Partners in Crime?

S Negri, P Faris, F Moccia - International Journal of Molecular Sciences, 2021 - mdpi.com
An increase in intracellular Ca2+ concentration ([Ca2+] i) controls virtually all endothelial
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …