Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus

L Cheng, J Wang, H Dai, Y Duan, Y An, L Shi, Y Lv… - Adipocyte, 2021 - Taylor & Francis
Mammalian adipose tissue can be divided into two major types, namely, white adipose
tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function …

The liver as an endocrine organ—linking NAFLD and insulin resistance

MJ Watt, PM Miotto, W De Nardo… - Endocrine …, 2019 - academic.oup.com
The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …

[HTML][HTML] Mechanisms of insulin resistance related to white, beige, and brown adipocytes

MP Czech - Molecular metabolism, 2020 - Elsevier
Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

Lipoprotein lipase and its regulators: an unfolding story

SA Wu, S Kersten, L Qi - Trends in Endocrinology & Metabolism, 2021 - cell.com
Lipoprotein lipase (LPL) is one of the most important factors in systemic lipid partitioning and
metabolism. It mediates intravascular hydrolysis of triglycerides packed in lipoproteins such …

Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8

KL Sylvers-Davie, BSJ Davies - American Journal of …, 2021 - journals.physiology.org
Triglyceride-rich lipoproteins deliver fatty acids to tissues for oxidation and for storage.
Release of fatty acids from circulating lipoprotein triglycerides is carried out by lipoprotein …

Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis

B Chaube, KM Citrin, M Sahraei, AK Singh… - Nature …, 2023 - nature.com
Abstract Angiopoietin-like 4 (ANGPTL4) is known to regulate various cellular and systemic
functions. However, its cell-specific role in endothelial cells (ECs) function and metabolic …

[HTML][HTML] Brown adipose tissue-derived exosomes mitigate the metabolic syndrome in high fat diet mice

X Zhou, Z Li, M Qi, P Zhao, Y Duan, G Yang, L Yuan - Theranostics, 2020 - ncbi.nlm.nih.gov
The ever-increasing incidence of obesity and related disorders impose serious challenges
on public health worldwide. Brown adipose tissue (BAT) has strong capacity for promoting …

The molecular brakes of adipose tissue lipolysis

Y Li, Z Li, DA Ngandiri, M Llerins Perez, A Wolf… - Frontiers in …, 2022 - frontiersin.org
Adaptation to changes in energy availability is pivotal for the survival of animals. Adipose
tissue, the body's largest reservoir of energy and a major source of metabolic fuel, exerts a …

ANGPTL4: a multifunctional protein involved in metabolism and vascular homeostasis

C Fernández-Hernando, Y Suárez - Current opinion in hematology, 2020 - journals.lww.com
Further determination of ANGPTL4 regulatory circuits and defining specific molecular events
that mediate its biological effects remain key to future ANGPTL4-based therapeutic …

Network pharmacology analysis and experimental validation to explore the mechanism of sea buckthorn flavonoids on hyperlipidemia

P Xiao, S Liu, Y Kuang, Z Jiang, Y Lin, Z Xie… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Sea buckthorn is popularly used as a herbal medicine and
food additive in the world. Sea buckthorn flavonoids (SF) is reported to have an ameliorative …