Kinesins are a family of molecular motors that travel unidirectionally along microtubule
tracks to fulfil their many roles in intracellular transport or cell division. Over the past few …

Most solid tumors are aneuploid, having a chromosome number that is not a multiple of the
haploid number, and many frequently mis-segregate whole chromosomes in a phenomenon …

Aneuploidy is one of the most obvious differences between normal and cancer cells.
However, there remains debate over how aneuploid cells arise and whether or not they are …

DNA repair and maintenance of genome stability are crucial to cellular and organismal
function, and defects in these processes have been implicated in cancer and ageing …

Chromosome congression during prometaphase culminates with the establishment of a
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more …

The DNA damage response (DDR) occurs in the context of chromatin, and architectural
features of chromatin have been implicated in DNA damage signaling and repair. Whereas …

The kinesin superfamily (KIF) is a group of proteins that share a highly conserved motor
domain. Except for some members, many KIF proteins have adenosine triphosphatase …

Proper chromosome segregation in eukaryotes is driven by a complex superstructure called
the mitotic spindle. Assembly, maintenance, and function of the spindle depend on …

The kinesin superfamily contains a conserved class of microtubule‐dependent molecular
motor proteins that possess an adenosine triphosphatase activity and motion characteristics …

Chromokinesins are microtubule plus end–directed motor proteins that bind to chromosome
arms. In Xenopus egg cell-free extracts, Xkid and Xklp1 are essential for bipolar spindle …